Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1174755..1175404 Replicon chromosome
Accession NZ_AP022465
Organism Enterobacter roggenkampii strain STW0522-66

Toxin (Protein)


Gene name higB Uniprot ID A0A1S2AEP5
Locus tag JLF42_RS05475 Protein ID WP_045416590.1
Coordinates 1175042..1175404 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A1S2AD04
Locus tag JLF42_RS05470 Protein ID WP_047746098.1
Coordinates 1174755..1175054 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JLF42_RS05460 1171179..1173152 + 1974 WP_063929709.1 PhoX family phosphatase -
JLF42_RS05465 1173256..1174644 + 1389 WP_055321775.1 phenylalanine transporter -
JLF42_RS05470 1174755..1175054 - 300 WP_047746098.1 helix-turn-helix transcriptional regulator Antitoxin
JLF42_RS05475 1175042..1175404 - 363 WP_045416590.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JLF42_RS05480 1175611..1176846 + 1236 WP_055321774.1 MFS transporter -
JLF42_RS05485 1176862..1177887 + 1026 WP_055321773.1 sugar phosphate isomerase/epimerase -
JLF42_RS05490 1177880..1179022 + 1143 WP_023293105.1 Gfo/Idh/MocA family oxidoreductase -
JLF42_RS05495 1179098..1180069 + 972 WP_021241589.1 LacI family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-87)


Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13908.76 Da        Isoelectric Point: 5.1960

>T35692 WP_045416590.1 NZ_AP022465:c1175404-1175042 [Enterobacter roggenkampii]
MWNVETTDRFDDWFFEQTTALKEDVLATMHILAEFGPTLGRPYVDTVKDSAYANMKELRIQHAGNPIRAFFAFDPDRKAI
VLCAGDKTGCNQKRFYNEMIALADVEYSRHLADKEAIWQR

Download         Length: 363 bp

>T35692 NZ_AP022465:c1175404-1175042 [Enterobacter roggenkampii]
ATGTGGAACGTCGAGACAACGGACAGATTTGACGACTGGTTCTTTGAACAAACAACAGCATTAAAAGAAGATGTGCTGGC
GACGATGCATATTCTTGCTGAATTTGGCCCAACCCTGGGGCGACCATACGTAGACACCGTGAAGGATTCAGCCTATGCGA
ACATGAAAGAGTTACGTATTCAGCATGCGGGTAATCCCATCAGAGCCTTTTTTGCTTTTGATCCTGACCGTAAGGCAATT
GTGCTCTGTGCTGGAGACAAAACCGGTTGCAATCAAAAACGGTTTTATAACGAAATGATCGCGCTGGCTGACGTTGAATA
CAGCAGACATCTGGCGGATAAGGAGGCCATATGGCAACGCTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10906.70 Da        Isoelectric Point: 9.8627

>AT35692 WP_047746098.1 NZ_AP022465:c1175054-1174755 [Enterobacter roggenkampii]
MATLKELMAQQSAESQERIAAKVEVMRRIVALNQLREELNISQTELAAAMGVKQPTLAKIEQPGNDPRLSTLKRYVSALG
GEMSIDVTLPNGKRIAFQI

Download         Length: 300 bp

>AT35692 NZ_AP022465:c1175054-1174755 [Enterobacter roggenkampii]
ATGGCAACGCTAAAAGAACTCATGGCACAACAGAGCGCGGAAAGTCAGGAGCGTATAGCGGCTAAAGTTGAAGTGATGCG
CAGAATTGTTGCCCTGAACCAGCTGCGGGAAGAGCTCAATATTTCCCAGACAGAACTGGCCGCAGCAATGGGGGTAAAAC
AACCCACTTTGGCAAAAATCGAACAGCCGGGAAACGATCCCCGGCTTTCAACACTCAAACGCTATGTCAGTGCGCTCGGC
GGTGAAATGAGCATTGATGTGACGCTACCGAATGGGAAACGGATAGCGTTTCAGATTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1S2AEP5

Antitoxin

Source ID Structure
AlphaFold DB A0A1S2AD04

References