Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) ldrD-rdlD/Ldr(toxin)
Location 2236347..2236568 Replicon chromosome
Accession NZ_AP022362
Organism Escherichia coli strain E302

Toxin (Protein)


Gene name ldrD Uniprot ID A0A1U9U3P9
Locus tag G6M96_RS11140 Protein ID WP_001531632.1
Coordinates 2236347..2236454 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name rdlD
Locus tag -
Coordinates 2236502..2236568 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6M96_RS11115 2232191..2233273 + 1083 WP_000804726.1 peptide chain release factor 1 -
G6M96_RS11120 2233273..2234106 + 834 WP_000456450.1 peptide chain release factor N(5)-glutamine methyltransferase -
G6M96_RS11125 2234103..2234495 + 393 WP_000200375.1 invasion regulator SirB2 -
G6M96_RS11130 2234499..2235308 + 810 WP_001257044.1 invasion regulator SirB1 -
G6M96_RS11135 2235344..2236198 + 855 WP_000811065.1 3-deoxy-8-phosphooctulonate synthase -
G6M96_RS11140 2236347..2236454 - 108 WP_001531632.1 type I toxin-antitoxin system toxin Ldr family protein Toxin
- 2236502..2236568 + 67 NuclAT_10 - Antitoxin
- 2236502..2236568 + 67 NuclAT_10 - Antitoxin
- 2236502..2236568 + 67 NuclAT_10 - Antitoxin
- 2236502..2236568 + 67 NuclAT_10 - Antitoxin
- 2236502..2236568 + 67 NuclAT_5 - Antitoxin
- 2236502..2236568 + 67 NuclAT_5 - Antitoxin
- 2236502..2236568 + 67 NuclAT_5 - Antitoxin
- 2236502..2236568 + 67 NuclAT_5 - Antitoxin
- 2236502..2236568 + 67 NuclAT_6 - Antitoxin
- 2236502..2236568 + 67 NuclAT_6 - Antitoxin
- 2236502..2236568 + 67 NuclAT_6 - Antitoxin
- 2236502..2236568 + 67 NuclAT_6 - Antitoxin
- 2236502..2236568 + 67 NuclAT_7 - Antitoxin
- 2236502..2236568 + 67 NuclAT_7 - Antitoxin
- 2236502..2236568 + 67 NuclAT_7 - Antitoxin
- 2236502..2236568 + 67 NuclAT_7 - Antitoxin
- 2236502..2236568 + 67 NuclAT_8 - Antitoxin
- 2236502..2236568 + 67 NuclAT_8 - Antitoxin
- 2236502..2236568 + 67 NuclAT_8 - Antitoxin
- 2236502..2236568 + 67 NuclAT_8 - Antitoxin
- 2236502..2236568 + 67 NuclAT_9 - Antitoxin
- 2236502..2236568 + 67 NuclAT_9 - Antitoxin
- 2236502..2236568 + 67 NuclAT_9 - Antitoxin
- 2236502..2236568 + 67 NuclAT_9 - Antitoxin
- 2236504..2236567 + 64 NuclAT_12 - -
- 2236504..2236567 + 64 NuclAT_12 - -
- 2236504..2236567 + 64 NuclAT_12 - -
- 2236504..2236567 + 64 NuclAT_12 - -
- 2236504..2236567 + 64 NuclAT_13 - -
- 2236504..2236567 + 64 NuclAT_13 - -
- 2236504..2236567 + 64 NuclAT_13 - -
- 2236504..2236567 + 64 NuclAT_13 - -
- 2236504..2236567 + 64 NuclAT_14 - -
- 2236504..2236567 + 64 NuclAT_14 - -
- 2236504..2236567 + 64 NuclAT_14 - -
- 2236504..2236567 + 64 NuclAT_14 - -
- 2236504..2236567 + 64 NuclAT_15 - -
- 2236504..2236567 + 64 NuclAT_15 - -
- 2236504..2236567 + 64 NuclAT_15 - -
- 2236504..2236567 + 64 NuclAT_15 - -
- 2236504..2236567 + 64 NuclAT_16 - -
- 2236504..2236567 + 64 NuclAT_16 - -
- 2236504..2236567 + 64 NuclAT_16 - -
- 2236504..2236567 + 64 NuclAT_16 - -
- 2236504..2236567 + 64 NuclAT_17 - -
- 2236504..2236567 + 64 NuclAT_17 - -
- 2236504..2236567 + 64 NuclAT_17 - -
- 2236504..2236567 + 64 NuclAT_17 - -
- 2236504..2236569 + 66 NuclAT_18 - -
- 2236504..2236569 + 66 NuclAT_18 - -
- 2236504..2236569 + 66 NuclAT_18 - -
- 2236504..2236569 + 66 NuclAT_18 - -
- 2236504..2236569 + 66 NuclAT_19 - -
- 2236504..2236569 + 66 NuclAT_19 - -
- 2236504..2236569 + 66 NuclAT_19 - -
- 2236504..2236569 + 66 NuclAT_19 - -
- 2236504..2236569 + 66 NuclAT_20 - -
- 2236504..2236569 + 66 NuclAT_20 - -
- 2236504..2236569 + 66 NuclAT_20 - -
- 2236504..2236569 + 66 NuclAT_20 - -
- 2236504..2236569 + 66 NuclAT_21 - -
- 2236504..2236569 + 66 NuclAT_21 - -
- 2236504..2236569 + 66 NuclAT_21 - -
- 2236504..2236569 + 66 NuclAT_21 - -
- 2236504..2236569 + 66 NuclAT_22 - -
- 2236504..2236569 + 66 NuclAT_22 - -
- 2236504..2236569 + 66 NuclAT_22 - -
- 2236504..2236569 + 66 NuclAT_22 - -
- 2236504..2236569 + 66 NuclAT_23 - -
- 2236504..2236569 + 66 NuclAT_23 - -
- 2236504..2236569 + 66 NuclAT_23 - -
- 2236504..2236569 + 66 NuclAT_23 - -
G6M96_RS11145 2236859..2237959 - 1101 WP_000063608.1 sodium-potassium/proton antiporter ChaA -
G6M96_RS11150 2238229..2238468 + 240 WP_000120702.1 putative cation transport regulator ChaB -
G6M96_RS11155 2238617..2239312 + 696 WP_001295621.1 glutathione-specific gamma-glutamylcyclotransferase -
G6M96_RS11160 2239356..2239709 - 354 WP_001169659.1 DsrE/F sulfur relay family protein YchN -
G6M96_RS11165 2239894..2241288 + 1395 WP_000086187.1 inverse autotransporter invasin YchO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)


Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4040.89 Da        Isoelectric Point: 12.5163

>T35457 WP_001531632.1 NZ_AP022362:c2236454-2236347 [Escherichia coli]
MTLAQFAMIFWHNLAAPILAGIITAVIVSWWRNRK

Download         Length: 108 bp

>T35457 NZ_AP022362:c2236454-2236347 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACAACCTGGCGGCACCGATCCTGGCGGGGATTATTACCGCAGTGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 67 bp

>AT35457 NZ_AP022362:2236502-2236568 [Escherichia coli]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1U9U3P9

Antitoxin

Download structure file

References