Detailed information of TA system TA035399

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-RelB
• Location: 1092984..1093510
• Replicon: chromosome
• Accession: NZ_AP022347
• Organism: Fluviibacter phosphoraccumulans strain ICHIJ1

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: ICHIJ1_RS05605
• Protein ID: WP_162049678.1
• Coordinates: 1093244..1093510 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: ICHIJ1_RS05600
• Protein ID: WP_162049677.1
• Coordinates: 1092984..1093244 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ICHIJ1_RS05565	1088351..1089010	+	660	WP_162049670.1	type II toxin-antitoxin system MqsA family antitoxin	-
ICHIJ1_RS05570	1089007..1089462	+	456	WP_162049671.1	protein-export chaperone SecB	-
ICHIJ1_RS05575	1089540..1090406	+	867	WP_162049672.1	hypothetical protein	-
ICHIJ1_RS05580	1090474..1090731	+	258	WP_162049673.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
ICHIJ1_RS05585	1090728..1091006	+	279	WP_162049674.1	plasmid stabilization protein	-
ICHIJ1_RS05590	1091089..1092093	+	1005	WP_162049675.1	glycosyl transferase	-
ICHIJ1_RS05595	1092099..1092758	+	660	WP_162049676.1	transcriptional regulator	-
ICHIJ1_RS05600	1092984..1093244	+	261	WP_162049677.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
ICHIJ1_RS05605	1093244..1093510	+	267	WP_162049678.1	Txe/YoeB family addiction module toxin	Toxin
ICHIJ1_RS05610	1093579..1094049	+	471	WP_162049679.1	hypothetical protein	-
ICHIJ1_RS05615	1094068..1095015	+	948	WP_202930691.1	hypothetical protein	-
ICHIJ1_RS05620	1095030..1096334	+	1305	WP_202930690.1	glycosyltransferase family 4 protein	-
ICHIJ1_RS05625	1096401..1096667	+	267	WP_162049680.1	ribbon-helix-helix protein, CopG family	-
ICHIJ1_RS05630	1096667..1096945	+	279	WP_162049681.1	type II toxin-antitoxin system RelE/ParE family toxin	-
ICHIJ1_RS05635	1096952..1097551	+	600	WP_162049682.1	adenylyl-sulfate kinase	-
ICHIJ1_RS05640	1097554..1098354	+	801	WP_162049683.1	3'(2'),5'-bisphosphate nucleotidase CysQ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	gmd / fcl	1058849..1102748	43899

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-86)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-75)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10276.69 Da
• Isoelectric Point: 7.9860

>T35399 WP_162049678.1 NZ_AP022347:1093244-1093510 [Fluviibacter phosphoraccumulans]
MARDIRFVPDAWADYLYWQEQDKKTLKRLNTLITGAARDPFVGIGKPEPLRGDLSGYWSRRIDDVNRLVYRATDTDLVII
ACRFHYDG

Nucleotide

• Length: 267 bp

>T35399 NZ_AP022347:1093244-1093510 [Fluviibacter phosphoraccumulans]
ATGGCTCGTGACATCCGTTTTGTCCCGGACGCATGGGCTGATTATCTGTATTGGCAAGAGCAGGACAAGAAGACGCTGAA
AAGATTGAATACTTTGATCACTGGCGCTGCACGTGACCCGTTTGTTGGTATAGGCAAACCGGAACCCTTACGTGGCGATT
TGTCAGGCTATTGGTCAAGACGGATCGATGATGTTAACCGCCTGGTTTATCGTGCAACCGATACGGATTTGGTGATTATT
GCGTGTCGGTTTCACTACGATGGTTGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9176.31 Da
• Isoelectric Point: 4.4536

>AT35399 WP_162049677.1 NZ_AP022347:1092984-1093244 [Fluviibacter phosphoraccumulans]
MKVVTYSEARNALKSILDGVVSDADVTIISRRDAEGDAVVMSLDSYNSIMETLHLTSNPANAAALARAIAQDKAGQVQVR
QLLSDD

Nucleotide

• Length: 261 bp

>AT35399 NZ_AP022347:1092984-1093244 [Fluviibacter phosphoraccumulans]
ATGAAAGTGGTGACTTATTCTGAGGCACGTAACGCGCTGAAGTCTATTTTGGATGGTGTGGTGTCGGATGCCGATGTAAC
GATCATTAGTCGTCGTGATGCCGAGGGTGATGCGGTTGTGATGTCGTTAGATAGCTACAACAGCATTATGGAAACCCTGC
ACCTCACCAGTAATCCTGCTAACGCTGCGGCTTTGGCCCGTGCCATTGCCCAGGATAAAGCTGGCCAGGTGCAGGTGCGC
CAGCTGCTGTCGGATGATTAA