35305

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 157394..158066 Replicon chromosome
Accession NZ_AP022315
Organism Burkholderia sp. THE68

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag BTHE68_RS00785 Protein ID WP_162066728.1
Coordinates 157719..158066 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag BTHE68_RS00780 Protein ID WP_162064726.1
Coordinates 157394..157726 (-) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BTHE68_RS00750 152461..153462 + 1002 WP_162064721.1 MerR family transcriptional regulator -
BTHE68_RS00755 153859..154734 + 876 WP_162064722.1 acyl-ACP desaturase -
BTHE68_RS00760 154874..155356 + 483 WP_162064723.1 D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase -
BTHE68_RS00765 155372..155611 - 240 WP_061172637.1 hypothetical protein -
BTHE68_RS00770 155641..156462 - 822 WP_162064724.1 type III pantothenate kinase -
BTHE68_RS00775 156459..157346 - 888 WP_162064725.1 biotin--[acetyl-CoA-carboxylase] ligase -
BTHE68_RS00780 157394..157726 - 333 WP_162064726.1 helix-turn-helix domain-containing protein Antitoxin
BTHE68_RS00785 157719..158066 - 348 WP_162066728.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BTHE68_RS00790 158252..159379 + 1128 WP_162064727.1 ABC transporter permease -
BTHE68_RS00795 159385..160263 + 879 WP_162064728.1 ATP-binding cassette domain-containing protein -
BTHE68_RS00800 160312..161271 + 960 WP_162064729.1 MCE family protein -
BTHE68_RS00805 161290..161913 + 624 WP_162064730.1 membrane integrity-associated transporter subunit PqiC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(20-109)

Antitoxin

Cro/C1-type helix-turn-helix domain

(52-105)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13612.79 Da        Isoelectric Point: 9.9629

>T35305 WP_162066728.1 NZ_AP022315:c158066-157719 [Burkholderia sp. THE68]
MLTSYDHGWTITYFDEQLRDEIYDLPAGIRSDYWRLVDLMKIHGANLRMPHSKSMGEGLFELRPHGKEGVGRVFYCMTIG
RRIVMLHAFVKKTRRTPDDELRIARERMKEVKRNG

Download         Length: 348 bp

>T35305 NZ_AP022315:c158066-157719 [Burkholderia sp. THE68]
ATGCTAACATCTTATGACCACGGTTGGACCATAACGTACTTCGACGAACAACTTCGCGATGAAATTTACGACCTGCCGGC
CGGAATTCGCTCGGACTACTGGCGGCTGGTGGATCTCATGAAAATCCACGGTGCGAATTTGCGAATGCCCCATTCAAAAT
CGATGGGGGAAGGACTGTTCGAACTCCGGCCACACGGTAAGGAAGGCGTGGGCCGCGTCTTTTATTGCATGACCATTGGC
AGACGGATCGTCATGCTGCATGCCTTCGTCAAGAAGACCAGGCGAACGCCCGACGATGAACTGCGAATTGCGCGAGAGCG
AATGAAGGAGGTGAAAAGAAATGGCTAA

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 12212.02 Da        Isoelectric Point: 10.0003

>AT35305 WP_162064726.1 NZ_AP022315:c157726-157394 [Burkholderia sp. THE68]
MAKTRLQRELERRYEPVAHTDEDTRRMLADPEFKAAYDALGPKYEALDALLRARKEAGLTQAQVAKHMKTTASAVARLEG
SLISGKHSPSLDTLHKYAAACGKTLRISFV

Download         Length: 333 bp

>AT35305 NZ_AP022315:c157726-157394 [Burkholderia sp. THE68]
ATGGCTAAAACCCGACTGCAACGCGAACTGGAACGGCGATATGAACCGGTCGCTCACACCGACGAAGACACCCGTCGCAT
GCTCGCCGACCCGGAATTCAAGGCGGCATATGACGCTCTGGGTCCCAAGTACGAAGCGCTCGATGCGCTGCTTCGCGCGC
GCAAGGAAGCAGGTCTGACGCAAGCGCAAGTGGCCAAGCACATGAAGACGACCGCGTCGGCCGTGGCGCGACTCGAAGGC
TCGCTGATCAGCGGAAAGCATTCACCTTCGCTCGATACGCTCCACAAATACGCAGCAGCCTGCGGCAAGACACTGCGGAT
CTCATTCGTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References