Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | I | Classification (family/domain) | hok-sok/- |
Location | 48206..48444 | Replicon | plasmid pBEC1-S17-ESBL-09_1 |
Accession | NZ_AP022299 | ||
Organism | Escherichia coli strain BEC1-S17-ESBL-09 |
Toxin (Protein)
Gene name | srnB | Uniprot ID | A0A762TWR7 |
Locus tag | H7R48_RS24720 | Protein ID | WP_023144756.1 |
Coordinates | 48310..48444 (+) | Length | 45 a.a. |
Antitoxin (RNA)
Gene name | sok | ||
Locus tag | - | ||
Coordinates | 48206..48257 (-) |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
H7R48_RS24700 | 45737..46483 | + | 747 | WP_000205736.1 | conjugal transfer pilus acetylase TraX | - |
H7R48_RS24705 | 46538..47098 | + | 561 | WP_000139341.1 | fertility inhibition protein FinO | - |
H7R48_RS24710 | 47229..47441 | + | 213 | WP_001301409.1 | ANR family transcriptional regulator | - |
H7R48_RS24715 | 47953..48239 | + | 287 | Protein_52 | DUF2726 domain-containing protein | - |
- | 48206..48257 | - | 52 | NuclAT_1 | - | Antitoxin |
- | 48206..48257 | - | 52 | NuclAT_1 | - | Antitoxin |
- | 48206..48257 | - | 52 | NuclAT_1 | - | Antitoxin |
- | 48206..48257 | - | 52 | NuclAT_1 | - | Antitoxin |
H7R48_RS24720 | 48310..48444 | + | 135 | WP_023144756.1 | type I toxin-antitoxin system Hok family toxin | Toxin |
H7R48_RS24725 | 48741..48995 | + | 255 | WP_000083850.1 | replication regulatory protein RepA | - |
H7R48_RS25800 | 49102..49236 | + | 135 | Protein_55 | protein CopA/IncA | - |
H7R48_RS24730 | 49233..49307 | + | 75 | WP_031943482.1 | RepA leader peptide Tap | - |
H7R48_RS24735 | 49300..50157 | + | 858 | WP_139451298.1 | incFII family plasmid replication initiator RepA | - |
H7R48_RS24740 | 51183..52720 | + | 1538 | WP_085950854.1 | IS3 family transposase | - |
H7R48_RS24745 | 52822..53370 | - | 549 | Protein_59 | IS21-like element ISEc12 family helper ATPase IstB | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Conjugative plasmid | - | pic / agg3D / agg3C / agg3B / agg3A / aap/aspU | 1..123266 | 123266 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 45 a.a. Molecular weight: 4896.90 Da Isoelectric Point: 7.7209
>T35285 WP_023144756.1 NZ_AP022299:48310-48444 [Escherichia coli]
MTKYTLIGLLAVCATVLCFSLIFREQLCELNIHRGNTVVQVTLA
MTKYTLIGLLAVCATVLCFSLIFREQLCELNIHRGNTVVQVTLA
Download Length: 135 bp
>T35285 NZ_AP022299:48310-48444 [Escherichia coli]
ATGACGAAATATACCCTTATCGGGTTGCTTGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACAGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTGA
ATGACGAAATATACCCTTATCGGGTTGCTTGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACAGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTGA
Antitoxin
Download Length: 52 bp
>AT35285 NZ_AP022299:c48257-48206 [Escherichia coli]
TCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT
TCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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