Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type I Classification (family/domain) hok-sok/-
Location 48206..48444 Replicon plasmid pBEC1-S17-ESBL-09_1
Accession NZ_AP022299
Organism Escherichia coli strain BEC1-S17-ESBL-09

Toxin (Protein)


Gene name srnB Uniprot ID A0A762TWR7
Locus tag H7R48_RS24720 Protein ID WP_023144756.1
Coordinates 48310..48444 (+) Length 45 a.a.

Antitoxin (RNA)


Gene name sok
Locus tag -
Coordinates 48206..48257 (-)

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H7R48_RS24700 45737..46483 + 747 WP_000205736.1 conjugal transfer pilus acetylase TraX -
H7R48_RS24705 46538..47098 + 561 WP_000139341.1 fertility inhibition protein FinO -
H7R48_RS24710 47229..47441 + 213 WP_001301409.1 ANR family transcriptional regulator -
H7R48_RS24715 47953..48239 + 287 Protein_52 DUF2726 domain-containing protein -
- 48206..48257 - 52 NuclAT_1 - Antitoxin
- 48206..48257 - 52 NuclAT_1 - Antitoxin
- 48206..48257 - 52 NuclAT_1 - Antitoxin
- 48206..48257 - 52 NuclAT_1 - Antitoxin
H7R48_RS24720 48310..48444 + 135 WP_023144756.1 type I toxin-antitoxin system Hok family toxin Toxin
H7R48_RS24725 48741..48995 + 255 WP_000083850.1 replication regulatory protein RepA -
H7R48_RS25800 49102..49236 + 135 Protein_55 protein CopA/IncA -
H7R48_RS24730 49233..49307 + 75 WP_031943482.1 RepA leader peptide Tap -
H7R48_RS24735 49300..50157 + 858 WP_139451298.1 incFII family plasmid replication initiator RepA -
H7R48_RS24740 51183..52720 + 1538 WP_085950854.1 IS3 family transposase -
H7R48_RS24745 52822..53370 - 549 Protein_59 IS21-like element ISEc12 family helper ATPase IstB -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - pic / agg3D / agg3C / agg3B / agg3A / aap/aspU 1..123266 123266


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(4-44)


Sequences


Toxin        


Download         Length: 45 a.a.        Molecular weight: 4896.90 Da        Isoelectric Point: 7.7209

>T35285 WP_023144756.1 NZ_AP022299:48310-48444 [Escherichia coli]
MTKYTLIGLLAVCATVLCFSLIFREQLCELNIHRGNTVVQVTLA

Download         Length: 135 bp

>T35285 NZ_AP022299:48310-48444 [Escherichia coli]
ATGACGAAATATACCCTTATCGGGTTGCTTGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACAGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTGA

Antitoxin


Download         Length: 52 bp

>AT35285 NZ_AP022299:c48257-48206 [Escherichia coli]
TCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A762TWR7


Antitoxin

Download structure file

References