35177

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3741823..3742480 Replicon chromosome
Accession NZ_AP022274
Organism Enterobacter cloacae strain WP8-W19-CRE-02

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag H7R70_RS17995 Protein ID WP_182946985.1
Coordinates 3741823..3742122 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag H7R70_RS18000 Protein ID WP_042715349.1
Coordinates 3742133..3742480 (+) Length 116 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H7R70_RS17985 3738174..3740366 + 2193 WP_182945827.1 type I secretion system permease/ATPase -
H7R70_RS17990 3740377..3741546 + 1170 WP_089598177.1 HlyD family efflux transporter periplasmic adaptor subunit -
H7R70_RS17995 3741823..3742122 + 300 WP_182946985.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H7R70_RS18000 3742133..3742480 + 348 WP_042715349.1 HigA family addiction module antidote protein Antitoxin
H7R70_RS18005 3742530..3743711 - 1182 WP_182945828.1 PLP-dependent aminotransferase family protein -
H7R70_RS18010 3743732..3744619 - 888 WP_042715351.1 LysR family transcriptional regulator -
H7R70_RS18015 3744717..3745319 + 603 WP_182945829.1 short chain dehydrogenase -
H7R70_RS18020 3745313..3746047 - 735 WP_182945830.1 class I SAM-dependent methyltransferase -
H7R70_RS18025 3746122..3747120 - 999 WP_100166240.1 transketolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(8-86)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11522.06 Da        Isoelectric Point: 9.3210

>T35177 WP_182946985.1 NZ_AP022274:3741823-3742122 [Enterobacter cloacae]
MINHFHDQWLMDFFLFGKSSNVIPSSLEAALARKLDIINAASSYRDLRSPPGNMYESLNPPLEGYSSIRVNRQYRLVFRW
TEGKADDLYLSPHKYTSHK

Download         Length: 300 bp

>T35177 NZ_AP022274:3741823-3742122 [Enterobacter cloacae]
ATGATTAATCATTTTCACGATCAATGGCTTATGGATTTTTTCCTCTTTGGAAAATCAAGCAACGTTATCCCATCAAGCCT
TGAGGCAGCCCTGGCGAGGAAGCTGGATATCATCAATGCAGCATCCTCATATCGGGATTTGCGATCCCCACCAGGTAACA
TGTATGAATCGTTGAATCCTCCACTGGAAGGATATTCCTCAATTCGCGTGAACAGGCAATACAGATTGGTATTCAGATGG
ACTGAGGGCAAAGCGGACGATCTCTACCTCTCTCCCCACAAATACACATCGCACAAATGA

Antitoxin


Download         Length: 116 a.a.        Molecular weight: 13096.09 Da        Isoelectric Point: 7.0139

>AT35177 WP_042715349.1 NZ_AP022274:3742133-3742480 [Enterobacter cloacae]
MTLQQALRKPTTPGDVLQYEYLEPLNLKISDLAEMLNVHRNTISALVNNNRKLTADMAIKLAKAFDTTIEFWLNLQLNVD
IWEAQSNARTQEELSRIKTVVEIMAKRKSGQPDVA

Download         Length: 348 bp

>AT35177 NZ_AP022274:3742133-3742480 [Enterobacter cloacae]
ATGACCCTTCAACAAGCTCTGAGAAAACCCACCACGCCGGGTGACGTGCTGCAGTATGAGTATCTTGAACCGCTAAATCT
CAAAATTAGCGATCTGGCGGAGATGCTTAATGTACACCGCAATACCATCAGCGCATTGGTCAATAACAACCGCAAGCTTA
CTGCCGATATGGCGATCAAACTGGCAAAAGCCTTTGATACCACTATTGAATTTTGGCTGAACTTGCAACTGAACGTCGAT
ATCTGGGAAGCGCAATCTAACGCCAGGACGCAGGAGGAGTTGAGCCGTATAAAGACGGTGGTGGAAATAATGGCTAAAAG
GAAATCCGGTCAGCCGGATGTGGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References