35176

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3123374..3124034 Replicon chromosome
Accession NZ_AP022274
Organism Enterobacter cloacae strain WP8-W19-CRE-02

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag H7R70_RS15245 Protein ID WP_182945658.1
Coordinates 3123681..3124034 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag H7R70_RS15240 Protein ID WP_182945657.1
Coordinates 3123374..3123676 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H7R70_RS15220 3118410..3119735 + 1326 WP_100165963.1 SidA/IucD/PvdA family monooxygenase -
H7R70_RS15225 3119762..3121951 + 2190 WP_100165962.1 TonB-dependent siderophore receptor -
H7R70_RS15235 3122286..3123245 - 960 Protein_2984 zinc-binding alcohol dehydrogenase family protein -
H7R70_RS15240 3123374..3123676 - 303 WP_182945657.1 XRE family transcriptional regulator Antitoxin
H7R70_RS15245 3123681..3124034 - 354 WP_182945658.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H7R70_RS15250 3124273..3125223 - 951 WP_010432106.1 HTH-type transcriptional regulator Cbl -
H7R70_RS15255 3125320..3126237 - 918 WP_010432103.1 nitrogen assimilation transcriptional regulator NAC -
H7R70_RS15265 3126778..3127674 - 897 WP_182945659.1 L,D-transpeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-79)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13623.53 Da        Isoelectric Point: 9.5698

>T35176 WP_182945658.1 NZ_AP022274:c3124034-3123681 [Enterobacter cloacae]
VWTINTTDRFDRWFTSLDDTDRASVLAAMLVLREKGPGLSRPYADTLKGSRHSNMKELRIQSKGDPLRAFFAFDPNRTGI
MLCAGNKVGSERRFYDEMLLVADREFTYWLNKLKERE

Download         Length: 354 bp

>T35176 NZ_AP022274:c3124034-3123681 [Enterobacter cloacae]
GTGTGGACAATTAATACGACGGATAGGTTTGATCGCTGGTTCACTTCGCTTGACGATACCGATCGCGCCAGCGTACTTGC
AGCAATGCTTGTTTTGCGAGAGAAGGGGCCGGGTTTATCGAGACCCTACGCTGATACGCTTAAAGGCTCTCGTCACAGCA
ACATGAAAGAGCTACGTATTCAGAGTAAGGGGGATCCATTGCGGGCGTTTTTCGCATTTGACCCAAACCGTACCGGCATC
ATGCTTTGTGCTGGCAATAAGGTCGGCAGTGAAAGGCGATTCTACGATGAGATGCTTCTCGTTGCTGACCGGGAATTCAC
TTACTGGCTGAATAAATTAAAAGAGAGGGAATAG

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11059.84 Da        Isoelectric Point: 6.2298

>AT35176 WP_182945657.1 NZ_AP022274:c3123676-3123374 [Enterobacter cloacae]
MGRTLEQLIADEKPEVVASAQAIATDILLNIHLAELREKVHKTQVEMAQALGIRQPTVAVMEKPGRDLKLSSLKRYVEAA
GGKLRLDVELPDGSHYEFVL

Download         Length: 303 bp

>AT35176 NZ_AP022274:c3123676-3123374 [Enterobacter cloacae]
ATGGGAAGAACCCTTGAGCAGCTTATAGCGGATGAAAAGCCGGAGGTTGTCGCCAGCGCTCAGGCGATAGCAACGGATAT
TTTGCTCAACATTCATCTGGCTGAGTTACGTGAGAAAGTACATAAAACCCAAGTAGAGATGGCACAGGCTCTGGGTATCA
GGCAGCCTACCGTTGCGGTAATGGAAAAGCCCGGGCGCGATTTGAAACTTTCTTCACTTAAACGTTACGTTGAGGCTGCG
GGCGGAAAGCTGCGGCTTGATGTTGAACTGCCAGATGGCTCGCATTATGAGTTTGTGCTGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References