Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3547438..3548143 Replicon chromosome
Accession NZ_AP022256
Organism Klebsiella sp. WP8-S18-ESBL-06

Toxin (Protein)


Gene name mqsR Uniprot ID -
Locus tag H7R76_RS16970 Protein ID WP_106924675.1
Coordinates 3547438..3547737 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID -
Locus tag H7R76_RS16975 Protein ID WP_106924676.1
Coordinates 3547739..3548143 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H7R76_RS16955 3544079..3544879 + 801 WP_106924672.1 glucosamine-6-phosphate deaminase -
H7R76_RS16960 3544937..3546085 + 1149 WP_106924673.1 N-acetylglucosamine-6-phosphate deacetylase -
H7R76_RS16965 3546094..3547314 + 1221 WP_182928313.1 ROK family transcriptional regulator -
H7R76_RS16970 3547438..3547737 + 300 WP_106924675.1 type II toxin-antitoxin system MqsR family toxin Toxin
H7R76_RS16975 3547739..3548143 + 405 WP_106924676.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
H7R76_RS16980 3548229..3548981 + 753 WP_106924677.1 HAD-IIA family hydrolase -
H7R76_RS16985 3549251..3550915 + 1665 WP_182965901.1 asparagine synthase B -
H7R76_RS16990 3551051..3553135 - 2085 WP_182965903.1 heavy metal translocating P-type ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(2-98)

Antitoxin

Cro/C1-type helix-turn-helix domain

(74-127)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11403.30 Da        Isoelectric Point: 10.3146

>T35103 WP_106924675.1 NZ_AP022256:3547438-3547737 [Klebsiella sp. WP8-S18-ESBL-06]
MEKRTPHTRLSILKNMARNGLVSITNTALISASQIGFRSKQDLLEVVMALNTSDFYKSMTAHHDHTIWHEVYRPIYRGQP
LYIKFIVSGNLLIVSFKEL

Download         Length: 300 bp

>T35103 NZ_AP022256:3547438-3547737 [Klebsiella sp. WP8-S18-ESBL-06]
ATGGAAAAGAGAACGCCGCATACCCGCTTAAGCATCCTAAAAAACATGGCCCGTAATGGTCTTGTCAGCATCACAAATAC
AGCGTTAATCAGCGCGTCTCAAATCGGATTTCGGTCAAAACAGGACCTCCTTGAGGTTGTTATGGCACTGAACACCAGCG
ATTTTTACAAAAGCATGACGGCGCATCATGACCACACCATCTGGCATGAGGTCTATCGCCCGATCTACAGAGGGCAGCCT
CTATACATAAAATTCATCGTATCAGGCAACCTCCTGATAGTGTCATTTAAGGAGCTATAG

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 15126.36 Da        Isoelectric Point: 8.0132

>AT35103 WP_106924676.1 NZ_AP022256:3547739-3548143 [Klebsiella sp. WP8-S18-ESBL-06]
MKCPLCGGAELKHECRNIPYEYKGNKTTFYGVKGQYCDACGEIIFGKGEGDAYMAGMVEFNRQVNAREVDPAFIARVRKS
LELDQRQAAEIFGGGANAFSRYETGRIAPPKPLILLFKTLEKHPEWFEELRKQA

Download         Length: 405 bp

>AT35103 NZ_AP022256:3547739-3548143 [Klebsiella sp. WP8-S18-ESBL-06]
ATGAAATGTCCTCTTTGCGGTGGTGCGGAACTCAAGCATGAATGTCGCAATATCCCCTATGAATACAAAGGGAATAAAAC
AACTTTTTACGGCGTAAAAGGCCAGTACTGTGACGCCTGCGGTGAAATTATCTTTGGCAAAGGTGAAGGCGATGCGTATA
TGGCTGGCATGGTGGAATTTAACCGCCAGGTCAATGCTCGTGAGGTTGACCCTGCGTTCATCGCCCGCGTACGAAAAAGT
CTGGAACTCGATCAGCGCCAGGCAGCAGAAATATTTGGCGGCGGCGCAAACGCCTTTAGCCGTTATGAAACGGGGCGAAT
TGCGCCCCCCAAGCCACTCATTCTGCTGTTTAAGACCTTAGAAAAACATCCTGAATGGTTCGAAGAGCTGAGAAAACAAG
CGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References