Detailed information of TA system TA034882

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 41065..41329
• Replicon: plasmid pWP7-S17-ESBL-04_2
• Accession: NZ_AP022179
• Organism: Escherichia coli strain WP7-S17-ESBL-04

Toxin (Protein)

• Gene name: pndA
• Uniprot ID: -
• Locus tag: H7R11_RS23605
• Protein ID: WP_042012216.1
• Coordinates: 41177..41329 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	pndB
Locus tag	-
Coordinates	41065..41122 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H7R11_RS23580	37317..37640	-	324	WP_078286536.1	IS66 family insertion sequence element accessory protein TnpB	-
H7R11_RS23590	38977..39411	-	435	WP_001421699.1	IS66 family insertion sequence hypothetical protein	-
H7R11_RS23595	39496..40470	-	975	Protein_51	IS256-like element IS1414 family transposase	-
H7R11_RS23600	40540..40854	-	315	Protein_52	conjugal transfer protein TrbC	-
-	41065..41122	-	58	NuclAT_0	-	Antitoxin
-	41065..41122	-	58	NuclAT_0	-	Antitoxin
-	41065..41122	-	58	NuclAT_0	-	Antitoxin
-	41065..41122	-	58	NuclAT_0	-	Antitoxin
H7R11_RS23605	41177..41329	+	153	WP_042012216.1	Hok/Gef family protein	Toxin
H7R11_RS23610	41576..42789	+	1214	WP_162829202.1	IS3 family transposase	-
H7R11_RS23615	42846..43181	-	336	Protein_55	DDE-type integrase/transposase/recombinase	-
H7R11_RS23620	43236..43913	+	678	WP_001339397.1	IS66 family insertion sequence hypothetical protein	-
H7R11_RS23625	43913..44260	+	348	WP_000624622.1	IS66 family insertion sequence element accessory protein TnpB	-
H7R11_RS23630	44280..45851	+	1572	WP_000381395.1	IS66 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Mobilizable plasmid	-	-	1..94173	94173
	-	inside	IScluster/Tn	-	-	35673..45851	10178

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (7-46)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5757.09 Da
• Isoelectric Point: 8.7948

>T34882 WP_042012216.1 NZ_AP022179:41177-41329 [Escherichia coli]
MPQRTFLMMLIVICVTILCFVWLVRDSLCGLRLQQGNTVLVATLAYEVKR

Nucleotide

• Length: 153 bp

>T34882 NZ_AP022179:41177-41329 [Escherichia coli]
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCATCTGTGTGACGATTCTGTGTTTTGTCTGGTTGGTGAGGGATTC
GCTTTGCGGACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTGGCCTACGAAGTTAAACGTTAA

Antitoxin

Nucleotide

• Length: 58 bp

>AT34882 NZ_AP022179:c41122-41065 [Escherichia coli]
GCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Structures

Antitoxin