Detailed information of TA system TA034848

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): symER/SymE(toxin)
• Location: 4451867..4452279
• Replicon: chromosome
• Accession: NZ_AP022173
• Organism: Escherichia coli strain WP7-S17-ESBL-01

Toxin (Protein)

• Gene name: symE
• Uniprot ID: U9YSY7
• Locus tag: H7R26_RS21585
• Protein ID: WP_000132601.1
• Coordinates: 4451867..4452208 (-)
• Length: 114 a.a.

Antitoxin (RNA)

Gene name	symR
Locus tag	-
Coordinates	4452203..4452279 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H7R26_RS21575	4449280..4450326	-	1047	WP_000437621.1	5-methylcytosine-specific restriction endonuclease system specificity protein McrC	-
H7R26_RS21580	4450326..4451705	-	1380	WP_000443951.1	5-methylcytosine-specific restriction endonuclease subunit McrB	-
H7R26_RS21585	4451867..4452208	-	342	WP_000132601.1	endoribonuclease SymE	Toxin
-	4452203..4452279	+	77	NuclAT_12	-	Antitoxin
-	4452203..4452279	+	77	NuclAT_12	-	Antitoxin
-	4452203..4452279	+	77	NuclAT_12	-	Antitoxin
-	4452203..4452279	+	77	NuclAT_12	-	Antitoxin
-	4452203..4452279	+	77	NuclAT_13	-	Antitoxin
-	4452203..4452279	+	77	NuclAT_13	-	Antitoxin
-	4452203..4452279	+	77	NuclAT_13	-	Antitoxin
-	4452203..4452279	+	77	NuclAT_13	-	Antitoxin
H7R26_RS21590	4452436..4453830	-	1395	WP_001272445.1	type I restriction-modification system specificity subunit	-
H7R26_RS21595	4453827..4455416	-	1590	WP_001063200.1	type I restriction-modification system methyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	4439584..4453830	14246

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (20-71)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12203.02 Da
• Isoelectric Point: 8.5012

>T34848 WP_000132601.1 NZ_AP022173:c4452208-4451867 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRHVTVGYASRYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPAAEESE
LMQSLRQVCKLSARKQKQVQAFIGVIAGKQKVA

Nucleotide

• Length: 342 bp

>T34848 NZ_AP022173:c4452208-4451867 [Escherichia coli]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCATGTCACCGTCGGTTA
TGCGAGTCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CTGGCACGGCGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGAGGAGAGCGAA
CTGATGCAGTCGCTACGCCAGGTGTGCAAACTGTCGGCGCGTAAACAAAAGCAGGTGCAGGCGTTTATTGGAGTGATTGC
CGGTAAACAGAAAGTCGCGTAA

Antitoxin

Nucleotide

• Length: 77 bp

>AT34848 NZ_AP022173:4452203-4452279 [Escherichia coli]
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGATGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Toxin

• AlphaFold DB: U9YSY7

Antitoxin