34786

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 185076..186394 Replicon chromosome
Accession NZ_AP022171
Organism Escherichia coli strain WP5-S18-ESBL-09

Toxin (Protein)


Gene name HipT Uniprot ID F4T5A3
Locus tag H7R27_RS00865 Protein ID WP_001262467.1
Coordinates 185387..186394 (+) Length 336 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID F4T5A4
Locus tag H7R27_RS00860 Protein ID WP_001312177.1
Coordinates 185076..185387 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H7R27_RS00835 180608..181627 + 1020 WP_000938855.1 dipeptide ABC transporter permease DppB -
H7R27_RS00840 181637..182539 + 903 WP_000084677.1 dipeptide ABC transporter permease DppC -
H7R27_RS00845 182550..183533 + 984 WP_001196477.1 dipeptide ABC transporter ATP-binding protein -
H7R27_RS00850 183530..184543 + 1014 WP_000103572.1 dipeptide ABC transporter ATP-binding subunit DppF -
H7R27_RS00855 184768..185091 + 324 WP_000563102.1 helix-turn-helix transcriptional regulator -
H7R27_RS00860 185076..185387 + 312 WP_001312177.1 HipA N-terminal domain-containing protein Antitoxin
H7R27_RS00865 185387..186394 + 1008 WP_001262467.1 HipA domain-containing protein Toxin
H7R27_RS00870 186411..187682 - 1272 WP_001545666.1 amino acid permease -
- 188044..188109 - 66 NuclAT_27 - -
- 188044..188109 - 66 NuclAT_27 - -
- 188044..188109 - 66 NuclAT_27 - -
- 188044..188109 - 66 NuclAT_27 - -
H7R27_RS00875 188158..188265 + 108 WP_001295224.1 type I toxin-antitoxin system toxin Ldr family protein -
- 188527..188584 - 58 NuclAT_26 - -
- 188527..188584 - 58 NuclAT_26 - -
- 188527..188584 - 58 NuclAT_26 - -
- 188527..188584 - 58 NuclAT_26 - -
H7R27_RS00880 188641..188748 + 108 WP_000170748.1 type I toxin-antitoxin system toxin Ldr family protein -
H7R27_RS00885 189124..189231 + 108 WP_001295224.1 type I toxin-antitoxin system toxin Ldr family protein -
H7R27_RS00890 189317..190996 - 1680 Protein_175 cellulose biosynthesis protein BcsG -
H7R27_RS00895 190993..191184 - 192 WP_000988308.1 cellulose biosynthesis protein BcsF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(56-302)

Antitoxin

HipA, N-terminal subdomain 1

(6-98)


Sequences

Toxin        


Download         Length: 336 a.a.        Molecular weight: 38320.60 Da        Isoelectric Point: 5.5965

>T34786 WP_001262467.1 NZ_AP022171:185387-186394 [Escherichia coli]
MANCRILLTPLNERDEQRGYSTQGLKRLSGTAKLTPRLGFTRTQFVQELPRQQKGMSISGYQPKLQLVLDEGEFRVVDHQ
GNFILKPSPADFPGLAENEHATMTLMSRLGFDVPVHGLLSFAPQSEEELEYAFVIRRYDRDNKGLPVHQEQLDGAMQIMD
KYGKTGNDNEQYVSYETLARFLVAHVNDNIAFKIDLFRRIVYAWLLGNNDMHLRNFGLVYSDGLTPALAPVYDFVSVAPY
PEYFHSNYLALPLLTREEGGRELAPGFHSDYGEYIGQDFLLLGESMGLAPRLLEKLFQDIRKENAIVMETYEQSFMTQDH
IQAVLQCYRHRLGLL

Download         Length: 1008 bp

>T34786 NZ_AP022171:185387-186394 [Escherichia coli]
ATGGCGAATTGTCGTATTCTGTTAACGCCGTTGAATGAACGTGACGAACAGCGCGGATATTCGACACAGGGGTTGAAGCG
ACTGAGCGGCACTGCAAAATTGACCCCCAGGCTGGGGTTTACGCGAACTCAGTTTGTGCAGGAACTTCCGCGTCAACAAA
AAGGGATGAGTATTTCCGGTTACCAGCCCAAATTGCAATTAGTGCTGGATGAAGGAGAGTTCCGCGTCGTAGATCATCAG
GGAAATTTTATCCTTAAGCCCTCTCCAGCCGACTTTCCCGGTTTGGCCGAAAATGAACACGCAACAATGACATTGATGTC
TCGTTTGGGATTTGACGTACCTGTGCATGGCCTGTTGAGTTTTGCACCACAATCAGAGGAAGAGCTTGAATACGCATTTG
TTATCCGGCGCTATGACCGGGATAACAAGGGGCTGCCAGTGCATCAGGAACAGCTTGATGGCGCGATGCAGATTATGGAT
AAATATGGCAAAACGGGGAATGATAACGAACAATATGTCAGCTATGAAACGCTGGCCCGATTTTTAGTTGCCCATGTTAA
CGACAACATCGCATTTAAAATCGATCTCTTTCGTCGCATTGTTTACGCCTGGTTGCTGGGTAATAACGACATGCATTTAC
GAAACTTTGGCTTAGTGTACTCCGATGGTTTGACGCCAGCGTTAGCGCCGGTGTATGACTTTGTTTCTGTCGCTCCCTAT
CCGGAATATTTTCACTCAAACTATCTGGCGCTGCCGTTATTGACGCGAGAAGAAGGCGGTCGGGAGCTGGCTCCTGGATT
TCACAGTGATTATGGCGAGTATATCGGGCAGGACTTTTTGCTGTTGGGTGAATCAATGGGGTTAGCGCCCAGATTGCTGG
AAAAACTCTTTCAGGATATACGTAAAGAAAATGCCATTGTTATGGAAACGTATGAGCAGTCCTTTATGACTCAGGATCAT
ATCCAGGCTGTGCTGCAATGCTATCGACATCGTCTGGGGCTGCTGTGA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11821.47 Da        Isoelectric Point: 6.0609

>AT34786 WP_001312177.1 NZ_AP022171:185076-185387 [Escherichia coli]
MHRRVKVLLYGQVVGELSQNDSGFLFQYAPDYHGPAISISLPVAQRQFPSEMLHPYFASLAPEGWLRQRYSQIQHRDEND
LLGMLIDNGKNLLGAIQILPWEE

Download         Length: 312 bp

>AT34786 NZ_AP022171:185076-185387 [Escherichia coli]
ATGCATCGGCGAGTGAAAGTGTTGCTCTATGGTCAGGTAGTGGGTGAACTCTCTCAGAACGACAGTGGTTTTTTGTTCCA
GTATGCCCCGGATTACCACGGACCGGCAATCTCAATCAGCCTGCCCGTCGCACAGCGTCAGTTTCCCAGTGAGATGTTGC
ATCCTTATTTCGCCTCACTGGCGCCAGAAGGATGGCTGCGTCAACGCTACAGCCAGATACAGCATCGTGACGAAAACGAT
CTGCTGGGAATGCTTATTGATAACGGCAAGAATCTGCTGGGGGCCATCCAGATTTTACCTTGGGAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3K2ZTB5

Antitoxin

Source ID Structure
AlphaFold DB A0A3L3HKE2

References