Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 607741..608540 Replicon chromosome
Accession NZ_AP022120
Organism Escherichia coli strain WP5-W18-ESBL-11

Toxin (Protein)


Gene name yhaV Uniprot ID F4VJD3
Locus tag H7R04_RS02960 Protein ID WP_000347266.1
Coordinates 607741..608205 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag H7R04_RS02965 Protein ID WP_001307405.1
Coordinates 608205..608540 (-) Length 112 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H7R04_RS02930 602742..603176 - 435 WP_000948824.1 PTS sugar transporter subunit IIA -
H7R04_RS02935 603194..604072 - 879 WP_001315856.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
H7R04_RS02940 604062..604841 - 780 WP_000406214.1 PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC -
H7R04_RS02945 604852..605325 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
H7R04_RS02950 605348..606628 - 1281 WP_000681921.1 tagatose-bisphosphate aldolase subunit KbaZ -
H7R04_RS02955 606877..607686 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
H7R04_RS02960 607741..608205 - 465 WP_000347266.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
H7R04_RS02965 608205..608540 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
H7R04_RS02970 608689..610260 - 1572 WP_001273741.1 galactarate dehydratase -
H7R04_RS02975 610635..611969 + 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
H7R04_RS02980 611985..612755 + 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 607741..619528 11787


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(12-150)

Antitoxin

(14-110)


Sequences


Toxin        


Download         Length: 155 a.a.        Molecular weight: 17841.18 Da        Isoelectric Point: 9.4947

>T34617 WP_000347266.1 NZ_AP022120:c608205-607741 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRFFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

>T34617 NZ_AP022120:c608205-607741 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTTTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT34617 WP_001307405.1 NZ_AP022120:c608540-608205 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp

>AT34617 NZ_AP022120:c608540-608205 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTCTTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A836NGD2


Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References