Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2493535..2494195 Replicon chromosome
Accession NZ_AP022112
Organism Klebsiella quasipneumoniae strain WP5-W18-ESBL-06

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag H7R83_RS12405 Protein ID WP_049092199.1
Coordinates 2493535..2493888 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag H7R83_RS12410 Protein ID WP_049092200.1
Coordinates 2493893..2494195 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H7R83_RS12380 2488549..2489574 + 1026 WP_001101446.1 IS110 family transposase -
H7R83_RS12385 2489869..2490837 + 969 WP_077259805.1 IS5 family transposase -
H7R83_RS12390 2491155..2492180 - 1026 WP_001101446.1 IS110 family transposase -
H7R83_RS12395 2492271..2492720 - 450 Protein_2445 hypothetical protein -
H7R83_RS12400 2492969..2493043 + 75 Protein_2446 helix-turn-helix domain-containing protein -
H7R83_RS12405 2493535..2493888 + 354 WP_049092199.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H7R83_RS12410 2493893..2494195 + 303 WP_049092200.1 XRE family transcriptional regulator Antitoxin
H7R83_RS12415 2494631..2495562 - 932 Protein_2449 integrase arm-type DNA-binding domain-containing protein -
H7R83_RS12425 2495926..2497362 - 1437 WP_180405678.1 EmmdR/YeeO family multidrug/toxin efflux MATE transporter -
H7R83_RS12435 2497913..2499016 + 1104 WP_065696911.1 phosphotransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-81)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13456.40 Da        Isoelectric Point: 9.9199

>T34608 WP_049092199.1 NZ_AP022112:2493535-2493888 [Klebsiella quasipneumoniae]
MWTIKTTDTFDRWFASLSDTDRVSMLAALLVLREKGPGLSRPYADTVRGSRYSNMKELRIQSRGAPIRAFFAFDPTRTGI
VLCAGNKVGNEKRFYDEMLPVADREFTNWLNTLKEKE

Download         Length: 354 bp

>T34608 NZ_AP022112:2493535-2493888 [Klebsiella quasipneumoniae]
ATGTGGACAATTAAAACAACGGATACGTTTGATCGCTGGTTTGCCTCGCTCAGCGATACCGACAGGGTCAGCATGCTTGC
AGCACTGCTGGTCCTGCGGGAAAAGGGACCAGGTTTGTCCAGACCTTATGCCGATACGGTCAGAGGTTCCCGCTACAGCA
ACATGAAAGAGCTACGTATTCAGAGTCGGGGCGCTCCGATACGGGCGTTTTTCGCTTTTGACCCGACCCGTACCGGCATT
GTGCTTTGTGCCGGAAATAAGGTCGGCAATGAAAAACGTTTTTACGATGAGATGCTCCCTGTTGCTGACAGGGAATTCAC
AAACTGGCTGAACACATTAAAAGAGAAGGAGTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11039.87 Da        Isoelectric Point: 7.2034

>AT34608 WP_049092200.1 NZ_AP022112:2493893-2494195 [Klebsiella quasipneumoniae]
MGRTLEQLIADEKPEVVAKAQAMATDILLNIHLAELREKVQKTQVEMAQALGIRQPTVAGMEKPGRDLKLSTLKRYVEAT
GGKLRLDVELPDGSHYGFVL

Download         Length: 303 bp

>AT34608 NZ_AP022112:2493893-2494195 [Klebsiella quasipneumoniae]
ATGGGCAGAACGCTGGAACAGCTTATTGCGGATGAAAAACCTGAAGTCGTGGCCAAAGCTCAGGCGATGGCAACGGACAT
ACTGCTCAACATTCACCTTGCCGAACTGCGTGAGAAAGTACAGAAAACGCAGGTGGAGATGGCACAAGCGCTGGGCATCA
GGCAACCTACCGTTGCAGGAATGGAAAAACCAGGGCGCGATCTGAAGCTTTCCACTCTCAAACGCTACGTTGAAGCGACT
GGCGGCAAGCTACGTCTTGATGTTGAACTGCCGGATGGTTCTCACTACGGATTTGTACTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References