Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 680089..680816 Replicon chromosome
Accession NZ_AP022095
Organism Escherichia coli strain WP4-S18-ESBL-08

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag H7R08_RS03250 Protein ID WP_108429971.1
Coordinates 680089..680403 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag H7R08_RS03255 Protein ID WP_000560266.1
Coordinates 680400..680816 (+) Length 139 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H7R08_RS03230 676247..677233 - 987 WP_001301393.1 Gfo/Idh/MocA family oxidoreductase -
H7R08_RS03235 677312..678004 - 693 WP_000942546.1 vancomycin high temperature exclusion protein -
H7R08_RS03240 678081..678584 - 504 WP_001300832.1 M48 family metallopeptidase -
H7R08_RS03245 678669..679805 + 1137 WP_000018695.1 23S rRNA (guanine(1835)-N(2))-methyltransferase RlmG -
H7R08_RS03250 680089..680403 + 315 WP_108429971.1 type II toxin-antitoxin system toxin HigB Toxin
H7R08_RS03255 680400..680816 + 417 WP_000560266.1 type II toxin-antitoxin system antitoxin HigA Antitoxin
H7R08_RS03260 680861..682879 - 2019 WP_000121449.1 NADPH-dependent 2,4-dienoyl-CoA reductase -
H7R08_RS03265 683305..685656 - 2352 WP_000695502.1 alpha-glucosidase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 105 a.a.        Molecular weight: 12054.03 Da        Isoelectric Point: 10.1027

>T34457 WP_108429971.1 NZ_AP022095:680089-680403 [Escherichia coli]
MHLITQKALKDAAEKNPQHKTELVALGNTIAKGYFKKPESLKAVFPSLDNFKYLDKHYVFNVGGNELRVVAMVFFESQKC
YIREVMTHKEYDFFTAVHRTKGKK

Download         Length: 315 bp

>T34457 NZ_AP022095:680089-680403 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAAAACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 14995.42 Da        Isoelectric Point: 4.4547

>AT34457 WP_000560266.1 NZ_AP022095:680400-680816 [Escherichia coli]
MIAIADILQAGEKLTAVAPFLAGIQNEEQYTQALELVDHLLLNDPENPLLDLVCAKITAWEESAPEFAEFNAMAQAMPGG
IAVIRTLMDQYGLTLSDLPEIGSKSMVSRVLSGKRKLTLEHAKKLATRFGISPALFID

Download         Length: 417 bp

>AT34457 NZ_AP022095:680400-680816 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure

References