Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 3436133..3436710 Replicon chromosome
Accession NZ_AP022057
Organism Klebsiella sp. WP4-W18-ESBL-05

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag H7R58_RS16455 Protein ID WP_182930209.1
Coordinates 3436381..3436710 (+) Length 110 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag H7R58_RS16450 Protein ID WP_106924166.1
Coordinates 3436133..3436384 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H7R58_RS16430 3432078..3433172 - 1095 WP_106924169.1 sulfate/thiosulfate ABC transporter ATP-binding protein CysA -
H7R58_RS16435 3433162..3434037 - 876 WP_106924168.1 sulfate/thiosulfate ABC transporter permease CysW -
H7R58_RS16440 3434037..3434870 - 834 WP_035897290.1 sulfate/thiosulfate ABC transporter permease CysT -
H7R58_RS16445 3434870..3435886 - 1017 WP_182930210.1 sulfate ABC transporter substrate-binding protein -
H7R58_RS16450 3436133..3436384 + 252 WP_106924166.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
H7R58_RS16455 3436381..3436710 + 330 WP_182930209.1 Txe/YoeB family addiction module toxin Toxin
H7R58_RS16460 3436671..3437570 - 900 WP_106924164.1 Dyp-type peroxidase -
H7R58_RS16465 3437668..3438243 - 576 WP_106924163.1 RpoE-regulated lipoprotein -
H7R58_RS16470 3438305..3438754 - 450 WP_182930208.1 DUF2919 domain-containing protein -
H7R58_RS16475 3438741..3439166 - 426 WP_181357945.1 GNAT family acetyltransferase -
H7R58_RS16480 3439380..3440249 + 870 WP_106924160.1 N-acetylmuramoyl-L-alanine amidase AmiA -
H7R58_RS16485 3440249..3441148 + 900 WP_182930207.1 oxygen-dependent coproporphyrinogen oxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12711.61 Da        Isoelectric Point: 9.8245

>T34302 WP_182930209.1 NZ_AP022057:3436381-3436710 [Klebsiella sp. WP4-W18-ESBL-05]
VKLIWSAQAWDDYLYWQNTDKSMIKKINELIRAIKRTPFVGKGKPEPLKFDLAGFWSRRITLEHRLVYKLDNDALLIAAC
RYHYQTARFMASEENAPYNATNLSSEGAK

Download         Length: 330 bp

>T34302 NZ_AP022057:3436381-3436710 [Klebsiella sp. WP4-W18-ESBL-05]
GTGAAACTTATCTGGTCAGCACAGGCATGGGACGATTATCTGTACTGGCAAAATACGGATAAAAGCATGATAAAAAAGAT
AAACGAGCTTATCAGGGCGATTAAACGCACGCCCTTTGTCGGCAAAGGTAAGCCAGAACCGCTGAAATTTGATCTGGCGG
GATTTTGGTCCCGCCGGATCACATTAGAGCATCGACTTGTCTACAAACTTGATAACGATGCTCTACTGATTGCGGCATGC
CGGTATCACTATCAGACGGCCCGTTTTATGGCATCTGAAGAGAATGCACCTTACAACGCCACTAACTTATCCAGCGAAGG
CGCAAAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9372.70 Da        Isoelectric Point: 4.8004

>AT34302 WP_106924166.1 NZ_AP022057:3436133-3436384 [Klebsiella sp. WP4-W18-ESBL-05]
MRIISDSEARQNLSTTLRQATEDRAPIIITQQNGKACVLMSLEEYRSLEETAYLMRSPANAGRLMDAIEELKTGKGIQRD
LME

Download         Length: 252 bp

>AT34302 NZ_AP022057:3436133-3436384 [Klebsiella sp. WP4-W18-ESBL-05]
ATGAGAATAATCAGCGATAGCGAAGCCCGGCAAAACCTATCCACAACGTTACGGCAAGCGACGGAAGACCGCGCCCCTAT
TATCATCACCCAACAAAACGGTAAGGCATGCGTGCTGATGTCGCTCGAAGAATACCGTTCGCTGGAAGAAACCGCTTATC
TGATGCGATCACCCGCAAATGCCGGACGACTCATGGATGCGATTGAGGAGCTAAAAACTGGAAAAGGTATCCAAAGGGAT
TTGATGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References