Detailed information of TA system TA034293

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 1429711..1430416
• Replicon: chromosome
• Accession: NZ_AP022057
• Organism: Klebsiella sp. WP4-W18-ESBL-05

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: -
• Locus tag: H7R58_RS06905
• Protein ID: WP_106924675.1
• Coordinates: 1430117..1430416 (-)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: -
• Locus tag: H7R58_RS06900
• Protein ID: WP_106924676.1
• Coordinates: 1429711..1430115 (-)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H7R58_RS06885	1424719..1426803	+	2085	WP_106924679.1	heavy metal translocating P-type ATPase	-
H7R58_RS06890	1426939..1428603	-	1665	WP_106924678.1	asparagine synthase B	-
H7R58_RS06895	1428873..1429625	-	753	WP_106924677.1	HAD-IIA family hydrolase	-
H7R58_RS06900	1429711..1430115	-	405	WP_106924676.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
H7R58_RS06905	1430117..1430416	-	300	WP_106924675.1	type II toxin-antitoxin system MqsR family toxin	Toxin
H7R58_RS06910	1430540..1431760	-	1221	WP_182928313.1	ROK family transcriptional regulator	-
H7R58_RS06915	1431769..1432917	-	1149	WP_106924673.1	N-acetylglucosamine-6-phosphate deacetylase	-
H7R58_RS06920	1432975..1433775	-	801	WP_106924672.1	glucosamine-6-phosphate deaminase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (2-98)

Antitoxin

• Cro/C1-type helix-turn-helix domain (74-127)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11403.30 Da
• Isoelectric Point: 10.3146

>T34293 WP_106924675.1 NZ_AP022057:c1430416-1430117 [Klebsiella sp. WP4-W18-ESBL-05]
MEKRTPHTRLSILKNMARNGLVSITNTALISASQIGFRSKQDLLEVVMALNTSDFYKSMTAHHDHTIWHEVYRPIYRGQP
LYIKFIVSGNLLIVSFKEL

Nucleotide

• Length: 300 bp

>T34293 NZ_AP022057:c1430416-1430117 [Klebsiella sp. WP4-W18-ESBL-05]
ATGGAAAAGAGAACGCCGCATACCCGATTAAGCATCCTAAAAAACATGGCCCGTAATGGTCTTGTCAGCATCACAAATAC
AGCGTTAATCAGCGCGTCTCAAATCGGATTTCGGTCAAAACAGGACCTCCTTGAGGTTGTTATGGCACTGAACACCAGCG
ATTTTTACAAAAGCATGACGGCGCATCATGACCACACCATCTGGCATGAGGTCTATCGCCCGATCTACAGAGGGCAGCCT
CTATACATAAAATTCATCGTATCAGGCAACCTCCTGATAGTGTCATTTAAGGAGCTATAG

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 15126.36 Da
• Isoelectric Point: 8.0132

>AT34293 WP_106924676.1 NZ_AP022057:c1430115-1429711 [Klebsiella sp. WP4-W18-ESBL-05]
MKCPLCGGAELKHECRNIPYEYKGNKTTFYGVKGQYCDACGEIIFGKGEGDAYMAGMVEFNRQVNAREVDPAFIARVRKS
LELDQRQAAEIFGGGANAFSRYETGRIAPPKPLILLFKTLEKHPEWFEELRKQA

Nucleotide

• Length: 405 bp

>AT34293 NZ_AP022057:c1430115-1429711 [Klebsiella sp. WP4-W18-ESBL-05]
ATGAAATGTCCTCTTTGTGGTGGTGCGGAACTCAAGCATGAATGTCGCAATATCCCCTATGAATACAAAGGGAATAAAAC
AACTTTTTACGGCGTAAAAGGCCAGTACTGTGACGCCTGCGGTGAAATTATCTTTGGCAAAGGTGAAGGCGATGCGTATA
TGGCTGGCATGGTGGAATTTAACCGCCAGGTCAATGCTCGTGAGGTTGACCCTGCGTTCATCGCCCGCGTACGAAAAAGT
CTGGAACTCGATCAGCGCCAGGCAGCAGAAATATTTGGCGGCGGCGCAAACGCCTTTAGCCGTTATGAAACGGGGCGAAT
TGCGCCCCCCAAGCCACTCATTCTGCTGTTTAAGACCTTAGAAAAACATCCTGAATGGTTCGAAGAGCTGAGAAAACAAG
CGTAA