Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | DinJ-YafQ (relBE)/YafQ-RelB |
| Location | 22620..23159 | Replicon | plasmid pWP3-W18-ESBL-02_3 |
| Accession | NZ_AP021975 | ||
| Organism | Klebsiella sp. WP3-W18-ESBL-02 | ||
Toxin (Protein)
| Gene name | yafQ | Uniprot ID | J2DZM3 |
| Locus tag | H7R56_RS27220 | Protein ID | WP_004150484.1 |
| Coordinates | 22620..22895 (-) | Length | 92 a.a. |
Antitoxin (Protein)
| Gene name | dinJ | Uniprot ID | A0A5H6MLU0 |
| Locus tag | H7R56_RS27225 | Protein ID | WP_001570852.1 |
| Coordinates | 22899..23159 (-) | Length | 87 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| H7R56_RS27165 | 17858..18304 | + | 447 | WP_045351267.1 | H-NS histone family protein | - |
| H7R56_RS27170 | 18357..18551 | - | 195 | WP_048242338.1 | hypothetical protein | - |
| H7R56_RS27175 | 18568..19107 | - | 540 | WP_045307794.1 | prepilin-type N-terminal cleavage/methylation domain-containing protein | - |
| H7R56_RS27180 | 19123..19680 | - | 558 | WP_053071116.1 | prepilin-type N-terminal cleavage/methylation domain-containing protein | - |
| H7R56_RS27185 | 19683..19994 | - | 312 | WP_048242340.1 | hypothetical protein | - |
| H7R56_RS27190 | 20130..20423 | - | 294 | WP_048242341.1 | hypothetical protein | - |
| H7R56_RS27195 | 20420..20719 | - | 300 | WP_048242342.1 | hypothetical protein | - |
| H7R56_RS27200 | 20716..20925 | - | 210 | WP_048242343.1 | hypothetical protein | - |
| H7R56_RS27205 | 20936..21463 | - | 528 | WP_048242344.1 | ankyrin repeat domain-containing protein | - |
| H7R56_RS27210 | 21795..22451 | + | 657 | WP_060437122.1 | hypothetical protein | - |
| H7R56_RS27215 | 22463..22669 | - | 207 | WP_162184628.1 | hypothetical protein | - |
| H7R56_RS27220 | 22620..22895 | - | 276 | WP_004150484.1 | type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family | Toxin |
| H7R56_RS27225 | 22899..23159 | - | 261 | WP_001570852.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| H7R56_RS27230 | 23421..23678 | - | 258 | WP_175149809.1 | hypothetical protein | - |
| H7R56_RS27235 | 24887..25144 | + | 258 | WP_175149809.1 | hypothetical protein | - |
| H7R56_RS27240 | 25335..25919 | - | 585 | WP_182928883.1 | hypothetical protein | - |
| H7R56_RS27245 | 25945..26457 | - | 513 | WP_175149770.1 | hypothetical protein | - |
| H7R56_RS27250 | 26457..26933 | - | 477 | WP_182928884.1 | hypothetical protein | - |
| H7R56_RS27255 | 27234..27419 | - | 186 | Protein_36 | hypothetical protein | - |
| H7R56_RS27260 | 27524..27826 | - | 303 | WP_048242310.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..42597 | 42597 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 92 a.a. Molecular weight: 10750.40 Da Isoelectric Point: 9.6586
>T34003 WP_004150484.1 NZ_AP021975:c22895-22620 [Klebsiella sp. WP3-W18-ESBL-02]
MTTRTIEYSGQFQKDVKKAQKRHKDMSKLKALMTLLINDALPLPQVYKDHPLQGNYKGYRDAHIEPDWLLIYKITDEVLR
FERTGTHSDLF
MTTRTIEYSGQFQKDVKKAQKRHKDMSKLKALMTLLINDALPLPQVYKDHPLQGNYKGYRDAHIEPDWLLIYKITDEVLR
FERTGTHSDLF
Download Length: 276 bp
>T34003 NZ_AP021975:c22895-22620 [Klebsiella sp. WP3-W18-ESBL-02]
ATGACCACAAGGACGATTGAATACTCAGGCCAGTTCCAGAAAGATGTGAAGAAGGCTCAGAAGCGTCATAAAGACATGAG
CAAGCTTAAAGCCCTTATGACGCTGTTAATCAATGATGCCTTGCCATTGCCTCAAGTCTACAAAGATCACCCACTACAGG
GGAACTACAAAGGCTATAGGGATGCTCACATAGAACCAGACTGGCTACTCATCTACAAGATAACTGATGAAGTCCTACGC
TTTGAGCGAACCGGAACACATTCAGACCTGTTTTGA
ATGACCACAAGGACGATTGAATACTCAGGCCAGTTCCAGAAAGATGTGAAGAAGGCTCAGAAGCGTCATAAAGACATGAG
CAAGCTTAAAGCCCTTATGACGCTGTTAATCAATGATGCCTTGCCATTGCCTCAAGTCTACAAAGATCACCCACTACAGG
GGAACTACAAAGGCTATAGGGATGCTCACATAGAACCAGACTGGCTACTCATCTACAAGATAACTGATGAAGTCCTACGC
TTTGAGCGAACCGGAACACATTCAGACCTGTTTTGA
Antitoxin
Download Length: 87 a.a. Molecular weight: 9239.63 Da Isoelectric Point: 5.0336
>AT34003 WP_001570852.1 NZ_AP021975:c23159-22899 [Klebsiella sp. WP3-W18-ESBL-02]
MAANAFVRARIDETLKNEAAVVLAGMGLTVSDLVRITLTKVAKEKALPFDMRVPNELTANTIANSEKGVDVHTAKDADDL
FNQLGI
MAANAFVRARIDETLKNEAAVVLAGMGLTVSDLVRITLTKVAKEKALPFDMRVPNELTANTIANSEKGVDVHTAKDADDL
FNQLGI
Download Length: 261 bp
>AT34003 NZ_AP021975:c23159-22899 [Klebsiella sp. WP3-W18-ESBL-02]
ATGGCCGCAAATGCATTTGTTCGTGCTCGTATAGATGAAACACTGAAAAATGAAGCTGCAGTAGTGCTTGCCGGAATGGG
TTTAACCGTTTCCGATCTGGTTCGTATCACTCTGACTAAGGTAGCCAAAGAAAAGGCTCTGCCGTTCGATATGCGTGTTC
CTAACGAGCTTACTGCTAATACCATCGCTAACAGTGAGAAAGGCGTAGACGTTCATACAGCTAAAGATGCTGATGATCTG
TTTAATCAGCTTGGTATCTGA
ATGGCCGCAAATGCATTTGTTCGTGCTCGTATAGATGAAACACTGAAAAATGAAGCTGCAGTAGTGCTTGCCGGAATGGG
TTTAACCGTTTCCGATCTGGTTCGTATCACTCTGACTAAGGTAGCCAAAGAAAAGGCTCTGCCGTTCGATATGCGTGTTC
CTAACGAGCTTACTGCTAATACCATCGCTAACAGTGAGAAAGGCGTAGACGTTCATACAGCTAAAGATGCTGATGATCTG
TTTAATCAGCTTGGTATCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | J2DZM3 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5H6MLU0 |