Detailed information of TA system TA033989

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 3575258..3575963
• Replicon: chromosome
• Accession: NZ_AP021972
• Organism: Klebsiella sp. WP3-W18-ESBL-02

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: -
• Locus tag: H7R56_RS17070
• Protein ID: WP_106924675.1
• Coordinates: 3575258..3575557 (+)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: -
• Locus tag: H7R56_RS17075
• Protein ID: WP_106924676.1
• Coordinates: 3575559..3575963 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H7R56_RS17055	3571898..3572698	+	801	WP_106924672.1	glucosamine-6-phosphate deaminase	-
H7R56_RS17060	3572757..3573905	+	1149	WP_106924673.1	N-acetylglucosamine-6-phosphate deacetylase	-
H7R56_RS17065	3573914..3575134	+	1221	WP_182928313.1	ROK family transcriptional regulator	-
H7R56_RS17070	3575258..3575557	+	300	WP_106924675.1	type II toxin-antitoxin system MqsR family toxin	Toxin
H7R56_RS17075	3575559..3575963	+	405	WP_106924676.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
H7R56_RS17080	3576049..3576801	+	753	WP_106924677.1	HAD-IIA family hydrolase	-
H7R56_RS17085	3577071..3578735	+	1665	WP_106924678.1	asparagine synthase B	-
H7R56_RS17090	3578871..3580955	-	2085	WP_106924679.1	heavy metal translocating P-type ATPase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (2-98)

Antitoxin

• Cro/C1-type helix-turn-helix domain (74-127)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11403.30 Da
• Isoelectric Point: 10.3146

>T33989 WP_106924675.1 NZ_AP021972:3575258-3575557 [Klebsiella sp. WP3-W18-ESBL-02]
MEKRTPHTRLSILKNMARNGLVSITNTALISASQIGFRSKQDLLEVVMALNTSDFYKSMTAHHDHTIWHEVYRPIYRGQP
LYIKFIVSGNLLIVSFKEL

Nucleotide

• Length: 300 bp

>T33989 NZ_AP021972:3575258-3575557 [Klebsiella sp. WP3-W18-ESBL-02]
ATGGAAAAGAGAACGCCGCATACCCGCTTAAGCATCCTAAAAAACATGGCCCGTAATGGTCTTGTCAGCATCACAAATAC
AGCGTTAATCAGCGCGTCTCAAATCGGATTTCGGTCAAAACAGGACCTCCTTGAGGTTGTTATGGCACTGAACACCAGCG
ATTTTTACAAAAGCATGACGGCGCATCATGACCACACCATCTGGCATGAGGTCTATCGCCCGATCTACAGAGGGCAGCCT
CTATACATAAAATTCATCGTATCAGGCAACCTCCTGATAGTGTCATTTAAGGAGCTATAG

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 15126.36 Da
• Isoelectric Point: 8.0132

>AT33989 WP_106924676.1 NZ_AP021972:3575559-3575963 [Klebsiella sp. WP3-W18-ESBL-02]
MKCPLCGGAELKHECRNIPYEYKGNKTTFYGVKGQYCDACGEIIFGKGEGDAYMAGMVEFNRQVNAREVDPAFIARVRKS
LELDQRQAAEIFGGGANAFSRYETGRIAPPKPLILLFKTLEKHPEWFEELRKQA

Nucleotide

• Length: 405 bp

>AT33989 NZ_AP021972:3575559-3575963 [Klebsiella sp. WP3-W18-ESBL-02]
ATGAAATGTCCTCTTTGTGGTGGTGCGGAACTCAAGCATGAATGTCGCAATATCCCCTATGAATACAAAGGGAATAAAAC
AACTTTTTACGGCGTAAAAGGCCAGTACTGTGACGCCTGCGGTGAAATTATCTTTGGCAAAGGTGAAGGCGATGCGTATA
TGGCTGGCATGGTGGAATTTAACCGCCAGGTCAATGCTCGTGAGGTTGACCCTGCGTTCATCGCCCGCGTACGAAAAAGT
CTGGAACTCGATCAGCGCCAGGCAGCAGAAATATTTGGCGGCGGCGCAAACGCCTTTAGCCGTTATGAAACGGGGCGAAT
TGCGCCCCCCAAGCCACTCATTCTGCTGTTTAAGACCTTAGAAAAACATCCTGAATGGTTCGAAGAGCTGAGAAAACAAG
CGTAA