Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 5668164..5668744 Replicon chromosome
Accession NZ_AP021903
Organism Pseudomonas sp. Seg1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag KI231_RS25455 Protein ID WP_103303632.1
Coordinates 5668164..5668442 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag KI231_RS25460 Protein ID WP_103303633.1
Coordinates 5668457..5668744 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KI231_RS25435 (PHLH6_50190) 5663568..5663735 - 168 WP_103303628.1 DUF2474 domain-containing protein -
KI231_RS25440 (PHLH6_50200) 5663818..5664825 - 1008 WP_103303629.1 cytochrome d ubiquinol oxidase subunit II -
KI231_RS25445 (PHLH6_50210) 5664829..5666274 - 1446 WP_213026640.1 cytochrome ubiquinol oxidase subunit I -
KI231_RS25450 (PHLH6_50220) 5666826..5668064 + 1239 WP_213026641.1 MFS transporter -
KI231_RS25455 (PHLH6_50230) 5668164..5668442 + 279 WP_103303632.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KI231_RS25460 (PHLH6_50240) 5668457..5668744 + 288 WP_103303633.1 HigA family addiction module antitoxin Antitoxin
KI231_RS25465 (PHLH6_50250) 5668750..5669301 - 552 WP_213026642.1 DJ-1/PfpI family protein -
KI231_RS25470 (PHLH6_50260) 5669369..5669818 - 450 WP_103303771.1 DUF4879 domain-containing protein -
KI231_RS25475 (PHLH6_50270) 5670041..5671336 + 1296 WP_103303635.1 NCS2 family permease -
KI231_RS25480 (PHLH6_50280) 5671333..5672412 + 1080 WP_103303636.1 tRNA (uridine(54)-C5)-methyltransferase TrmA -
KI231_RS25485 (PHLH6_50290) 5672468..5672914 - 447 WP_213026643.1 DUF2442 domain-containing protein -
KI231_RS30120 (PHLH6_50300) 5672911..5673339 - 429 WP_249412073.1 DUF4160 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(20-75)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10683.28 Da        Isoelectric Point: 9.8962

>T33682 WP_103303632.1 NZ_AP021903:5668164-5668442 [Pseudomonas sp. Seg1]
MIKSFQHKGLRGFYETGSTRGIRADHAKRLARMLQFMDRAALPADLDLPGWRLHPLKGELSTYWSLSVSGNWRVIFRFVG
SDIELVDYLDYH

Download         Length: 279 bp

>T33682 NZ_AP021903:5668164-5668442 [Pseudomonas sp. Seg1]
ATGATCAAATCCTTTCAGCACAAAGGCCTTCGTGGCTTCTATGAAACAGGTTCGACTCGCGGAATTCGCGCCGATCACGC
AAAACGGTTAGCGCGCATGCTGCAATTCATGGATCGCGCAGCGCTCCCCGCAGATCTTGATCTTCCAGGCTGGCGTTTGC
ATCCACTGAAGGGGGAGCTGTCGACATACTGGTCGCTCAGTGTTTCAGGCAACTGGCGGGTTATCTTTCGTTTTGTCGGT
TCGGACATCGAACTGGTCGATTATCTGGACTACCACTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10493.07 Da        Isoelectric Point: 6.6962

>AT33682 WP_103303633.1 NZ_AP021903:5668457-5668744 [Pseudomonas sp. Seg1]
MPMHNPPHPGETLLLDVLPELGISVTELARHLGFARPHLSRVLHGHAPISPDLAVRLERAGIGKARVWLGVQTDYDLWQA
EHREQPAIEPIAAHA

Download         Length: 288 bp

>AT33682 NZ_AP021903:5668457-5668744 [Pseudomonas sp. Seg1]
ATGCCCATGCACAACCCGCCACACCCCGGTGAAACACTGCTGCTGGATGTCTTGCCCGAGCTTGGCATCAGCGTGACCGA
ACTGGCACGGCACCTCGGCTTCGCTCGCCCGCATCTTTCCCGTGTATTGCATGGGCATGCGCCGATCAGCCCGGATCTGG
CCGTGCGGCTGGAGCGAGCAGGCATAGGCAAGGCACGCGTTTGGTTAGGTGTTCAAACCGACTACGATCTGTGGCAAGCG
GAACATCGGGAGCAACCGGCGATTGAACCTATCGCCGCGCACGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References