Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3692684..3693377 Replicon chromosome
Accession NZ_AP021892
Organism Escherichia coli strain 2018-01-1CC

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag HRR21_RS17635 Protein ID WP_000415584.1
Coordinates 3692684..3692980 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag HRR21_RS17640 Protein ID WP_000650107.1
Coordinates 3692982..3693377 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HRR21_RS17600 3687772..3688086 - 315 WP_000958598.1 antibiotic biosynthesis monooxygenase -
HRR21_RS17605 3688117..3688698 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
HRR21_RS17610 3689017..3689349 + 333 WP_000917684.1 DUF2645 family protein -
HRR21_RS17615 3689395..3690744 - 1350 WP_172409472.1 two-component system sensor histidine kinase QseC -
HRR21_RS17620 3690741..3691400 - 660 WP_001221493.1 two-component system response regulator QseB -
HRR21_RS17625 3691552..3691944 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
HRR21_RS17630 3691997..3692479 + 483 WP_000183505.1 transcriptional regulator -
HRR21_RS17635 3692684..3692980 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
HRR21_RS17640 3692982..3693377 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
HRR21_RS17645 3693510..3695117 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
HRR21_RS17650 3695255..3697513 + 2259 WP_049253102.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T33586 WP_000415584.1 NZ_AP021892:3692684-3692980 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T33586 NZ_AP021892:3692684-3692980 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT33586 WP_000650107.1 NZ_AP021892:3692982-3693377 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT33586 NZ_AP021892:3692982-3693377 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References