Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 108122..108624 Replicon chromosome
Accession NZ_AP021892
Organism Escherichia coli strain 2018-01-1CC

Toxin (Protein)


Gene name yoeB Uniprot ID A0A8E0FJZ4
Locus tag HRR21_RS00500 Protein ID WP_000767833.1
Coordinates 108370..108624 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag HRR21_RS00495 Protein ID WP_001259255.1
Coordinates 108122..108373 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HRR21_RS00470 103301..104368 - 1068 WP_170888132.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
HRR21_RS00475 104368..105438 - 1071 WP_000108970.1 histidinol-phosphate transaminase -
HRR21_RS00480 105435..106739 - 1305 WP_058905757.1 histidinol dehydrogenase -
HRR21_RS00485 106745..107644 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
HRR21_RS00490 107790..107840 - 51 WP_001364200.1 his operon leader peptide -
HRR21_RS00495 108122..108373 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
HRR21_RS00500 108370..108624 + 255 WP_000767833.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
HRR21_RS00505 108707..109531 + 825 WP_032202495.1 SDR family oxidoreductase -
HRR21_RS00510 109577..110506 + 930 WP_000803351.1 LysR family transcriptional regulator -
HRR21_RS00515 110721..110783 + 63 WP_010723108.1 membrane protein YoeI -
HRR21_RS00520 110773..112131 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
HRR21_RS00525 112310..113368 + 1059 WP_000492312.1 transport protein YeeE -
HRR21_RS00530 113382..113609 + 228 WP_000985278.1 sulfurtransferase TusA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10173.54 Da        Isoelectric Point: 8.0353

>T33568 WP_000767833.1 NZ_AP021892:108370-108624 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPESLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T33568 NZ_AP021892:108370-108624 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAATCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT33568 WP_001259255.1 NZ_AP021892:108122-108373 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT33568 NZ_AP021892:108122-108373 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAAGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References