Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1759650..1760152 Replicon chromosome
Accession NZ_AP021891
Organism Escherichia coli strain 2017.01.04CC

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag VEGS_RS08315 Protein ID WP_000767829.1
Coordinates 1759898..1760152 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag VEGS_RS08310 Protein ID WP_001259255.1
Coordinates 1759650..1759901 (+) Length 84 a.a.

Genomic Context

VEGS_RS08310VEGS_RS08315VEGS_RS08320VEGS_RS08325VEGS_RS08330VEGS_RS08335VEGS_RS08340VEGS_RS08345VEGS_RS08285VEGS_RS08290VEGS_RS08295VEGS_RS08300VEGS_RS08305
Location: 1759650..1759901 (252 bp)
Type: Antitoxin
Protein ID: WP_001259255.1
Location: 1759898..1760152 (255 bp)
Type: Toxin
Protein ID: WP_000767829.1
Location: 1760235..1761059 (825 bp)
Type: Others
Protein ID: WP_000754737.1
Location: 1761105..1762034 (930 bp)
Type: Others
Protein ID: WP_000803351.1
Location: 1762249..1762311 (63 bp)
Type: Others
Protein ID: WP_010723108.1
Location: 1762301..1763659 (1359 bp)
Type: Others
Protein ID: WP_172409711.1
Location: 1763838..1764896 (1059 bp)
Type: Others
Protein ID: WP_000492339.1
Location: 1764910..1765137 (228 bp)
Type: Others
Protein ID: WP_000234896.1
Location: 1754828..1755895 (1068 bp)
Type: Others
Protein ID: WP_000080128.1
Location: 1755895..1756965 (1071 bp)
Type: Others
Protein ID: WP_000108994.1
Location: 1756962..1758266 (1305 bp)
Type: Others
Protein ID: WP_024240936.1
Location: 1758272..1759171 (900 bp)
Type: Others
Protein ID: WP_000131782.1
Location: 1759317..1759367 (51 bp)
Type: Others
Protein ID: WP_001364200.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
VEGS_RS082851754828..1755895-1068WP_000080128.1bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB-
VEGS_RS082901755895..1756965-1071WP_000108994.1histidinol-phosphate transaminase-
VEGS_RS082951756962..1758266-1305WP_024240936.1histidinol dehydrogenase-
VEGS_RS083001758272..1759171-900WP_000131782.1ATP phosphoribosyltransferase-
VEGS_RS083051759317..1759367-51WP_001364200.1his operon leader peptide-
VEGS_RS083101759650..1759901+252WP_001259255.1YoeB-YefM toxin-antitoxin system antitoxin YefMAntitoxin
VEGS_RS083151759898..1760152+255WP_000767829.1type II toxin-antitoxin system mRNA interferase toxin YoeBToxin
VEGS_RS083201760235..1761059+825WP_000754737.1SDR family oxidoreductase-
VEGS_RS083251761105..1762034+930WP_000803351.1LysR family transcriptional regulator-
VEGS_RS083301762249..1762311+63WP_010723108.1membrane protein YoeI-
VEGS_RS083351762301..1763659+1359WP_172409711.1putrescine/proton symporter PlaP-
VEGS_RS083401763838..1764896+1059WP_000492339.1transport protein YeeE-
VEGS_RS083451764910..1765137+228WP_000234896.1sulfurtransferase TusA-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T33551 WP_000767829.1 NZ_AP021891:1759898-1760152 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T33551 NZ_AP021891:1759898-1760152 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT33551 WP_001259255.1 NZ_AP021891:1759650-1759901 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT33551 NZ_AP021891:1759650-1759901 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
PDB6NY6
PDB2A6S
PDB6OXA
PDB2A6R
PDB4V8X
PDB6OTR
PDB6OXI
PDB2A6Q

Antitoxin

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Source
ID
Structure
PDB2A6Q
AlphaFold DBA0A7U9LNR0

References