Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1522617..1523129 Replicon chromosome
Accession NZ_AP021887
Organism Streptococcus sp. 116-D4

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag UKS_RS07695 Protein ID WP_156012496.1
Coordinates 1522617..1522871 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag UKS_RS07700 Protein ID WP_173020499.1
Coordinates 1522875..1523129 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
UKS_RS07680 1519709..1520023 - 315 WP_049495305.1 DNA-directed RNA polymerase subunit omega -
UKS_RS07685 1520048..1520674 - 627 WP_156012494.1 guanylate kinase -
UKS_RS07690 1520802..1522415 - 1614 WP_156012495.1 ribonuclease Y -
UKS_RS07695 1522617..1522871 - 255 WP_156012496.1 Txe/YoeB family addiction module toxin Toxin
UKS_RS07700 1522875..1523129 - 255 WP_173020499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
UKS_RS07705 1523367..1524464 - 1098 WP_156012499.1 nucleotidyltransferase -
UKS_RS07710 1524488..1526299 - 1812 WP_156012501.1 NACHT domain-containing protein -
UKS_RS07715 1526340..1527080 - 741 WP_156013079.1 class I SAM-dependent methyltransferase -
UKS_RS07720 1527191..1527544 - 354 WP_156012503.1 ribosome silencing factor -
UKS_RS07725 1527557..1528057 - 501 WP_156012505.1 cysteine hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-75)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10115.55 Da        Isoelectric Point: 7.9716

>T33513 WP_156012496.1 NZ_AP021887:c1522871-1522617 [Streptococcus sp. 116-D4]
MLLKFTEDAWADYCYWQNQDKKTIKRINKLIKDIQRDPFTGIGKPEPLKYDYQGAWSRRIDAENRLLYMMDGDSVAFLSF
KDHY

Download         Length: 255 bp

>T33513 NZ_AP021887:c1522871-1522617 [Streptococcus sp. 116-D4]
ATGCTGCTCAAGTTTACAGAAGATGCCTGGGCAGATTATTGCTACTGGCAAAATCAGGATAAGAAAACGATAAAAAGAAT
CAATAAACTAATCAAGGATATTCAACGTGATCCCTTTACAGGAATAGGTAAGCCAGAACCACTCAAGTATGACTACCAAG
GAGCTTGGTCACGTCGTATTGATGCAGAAAATCGATTGCTTTATATGATGGATGGAGATAGCGTGGCTTTTTTGTCCTTC
AAAGATCATTACTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9677.94 Da        Isoelectric Point: 4.8430

>AT33513 WP_173020499.1 NZ_AP021887:c1523129-1522875 [Streptococcus sp. 116-D4]
MEAVLYSTFRNHLKDYMKKVNDEFEPLTVVNKNPDEDIVVLSKSEWDSIQETLRIAQNKELSDKVLRGMAQVRAGSTQVH
AIEE

Download         Length: 255 bp

>AT33513 NZ_AP021887:c1523129-1522875 [Streptococcus sp. 116-D4]
ATGGAAGCAGTTCTTTACTCAACATTCCGAAATCATTTAAAGGACTACATGAAAAAGGTAAATGATGAATTTGAGCCTTT
GACGGTGGTTAATAAAAATCCAGATGAGGACATTGTAGTTCTTTCAAAGAGTGAGTGGGATAGTATTCAAGAAACCCTGA
GAATCGCTCAAAATAAGGAGTTATCAGACAAGGTTTTGCGAGGAATGGCTCAAGTTCGTGCTGGAAGCACTCAAGTCCAT
GCTATTGAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References