Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2249085..2249684 Replicon chromosome
Accession NZ_AP021884
Organism Sulfuriferula plumbiphila strain Gro7

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag GZH91_RS11625 Protein ID WP_147071947.1
Coordinates 2249085..2249363 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag GZH91_RS11630 Protein ID WP_147071949.1
Coordinates 2249376..2249684 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GZH91_RS11605 2244343..2245350 + 1008 WP_147071943.1 hypothetical protein -
GZH91_RS11610 2245426..2246484 + 1059 WP_170227437.1 DMT family transporter -
GZH91_RS11615 2246623..2247744 + 1122 WP_147072008.1 class I SAM-dependent methyltransferase -
GZH91_RS11620 2247828..2249006 + 1179 WP_147071945.1 methionine adenosyltransferase -
GZH91_RS11625 2249085..2249363 + 279 WP_147071947.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GZH91_RS11630 2249376..2249684 + 309 WP_147071949.1 HigA family addiction module antidote protein Antitoxin
GZH91_RS11635 2250091..2250504 - 414 WP_147071951.1 hypothetical protein -
GZH91_RS11640 2250508..2250858 - 351 WP_147071953.1 hypothetical protein -
GZH91_RS11645 2251001..2251561 - 561 WP_147071955.1 elongation factor P -
GZH91_RS11650 2251607..2252752 - 1146 WP_147071958.1 elongation factor P maturation arginine rhamnosyltransferase EarP -
GZH91_RS11655 2252827..2253618 - 792 WP_147071959.1 slipin family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-71)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10785.45 Da        Isoelectric Point: 9.2810

>T33508 WP_147071947.1 NZ_AP021884:2249085-2249363 [Sulfuriferula plumbiphila]
MIQSFKCADTLALFAGSPTPRCVNIKTVAERKLQMLHRATRIDDLRIPPQNRLEKLKDNRKGAWSIRINDQWRVCFRYEE
GNALDVEIVDYH

Download         Length: 279 bp

>T33508 NZ_AP021884:2249085-2249363 [Sulfuriferula plumbiphila]
ATGATCCAGTCGTTCAAATGCGCCGACACACTGGCCTTGTTTGCTGGCAGTCCAACGCCACGATGCGTGAATATCAAGAC
GGTTGCCGAACGAAAATTGCAGATGCTGCATCGTGCCACCCGCATCGACGATTTGCGCATCCCCCCGCAAAACCGGCTGG
AAAAACTCAAAGACAACCGCAAGGGAGCCTGGAGCATTCGCATCAACGATCAATGGCGCGTCTGTTTCCGCTACGAAGAG
GGCAATGCATTGGATGTCGAAATCGTCGATTACCACTGA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11261.07 Da        Isoelectric Point: 7.2034

>AT33508 WP_147071949.1 NZ_AP021884:2249376-2249684 [Sulfuriferula plumbiphila]
MTVINGMRPIHPGEILREEFMIPLGLSANALAIALRVPAPRINDIARERRTVTADTALRLARYFGTSAEFWLGLQSDYDM
KITLAEHGARIEKDVAPMGQAA

Download         Length: 309 bp

>AT33508 NZ_AP021884:2249376-2249684 [Sulfuriferula plumbiphila]
ATGACAGTTATCAATGGAATGCGTCCAATTCACCCCGGTGAAATCCTGCGCGAAGAATTCATGATCCCGCTGGGACTGTC
TGCCAACGCGCTTGCCATCGCCTTGCGTGTACCCGCCCCACGCATCAACGACATCGCGCGCGAGCGCCGCACCGTCACCG
CCGACACCGCCCTGCGCCTGGCGCGCTATTTCGGCACCAGCGCGGAATTCTGGTTGGGCTTGCAATCGGACTACGACATG
AAAATCACTCTGGCCGAACATGGCGCGCGCATCGAGAAAGACGTGGCACCCATGGGACAGGCGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References