Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 411238..411842 Replicon chromosome
Accession NZ_AP021884
Organism Sulfuriferula plumbiphila strain Gro7

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag GZH91_RS02115 Protein ID WP_147073776.1
Coordinates 411238..411549 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag GZH91_RS02120 Protein ID WP_147073719.1
Coordinates 411552..411842 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GZH91_RS02100 407516..408535 + 1020 WP_198415367.1 toprim domain-containing protein -
GZH91_RS02105 408842..409906 + 1065 WP_147073723.1 DUF932 domain-containing protein -
GZH91_RS02110 410132..411169 + 1038 WP_147073721.1 IS630 family transposase -
GZH91_RS02115 411238..411549 + 312 WP_147073776.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GZH91_RS02120 411552..411842 + 291 WP_147073719.1 helix-turn-helix domain-containing protein Antitoxin
GZH91_RS02125 412020..412754 - 735 WP_161984146.1 S24 family peptidase -
GZH91_RS02130 413038..413373 + 336 WP_147073715.1 hypothetical protein -
GZH91_RS02135 413393..414007 + 615 WP_147073713.1 hypothetical protein -
GZH91_RS02140 414109..415908 + 1800 WP_147073711.1 TraI domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 410132..411169 1037


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(17-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-75)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12018.76 Da        Isoelectric Point: 5.8987

>T33504 WP_147073776.1 NZ_AP021884:411238-411549 [Sulfuriferula plumbiphila]
MEFIETPTFTRMVTALLSDDEYRELQNELVEDPERGDLIKGGGGIRKLRYAMQGRGKSGGVRLIYYWVKDNHQIYMLVVY
PKSKKDDLTDQETAILRNYVKEL

Download         Length: 312 bp

>T33504 NZ_AP021884:411238-411549 [Sulfuriferula plumbiphila]
ATGGAATTCATCGAGACCCCAACCTTCACCCGCATGGTCACGGCACTGCTATCCGATGATGAGTACCGAGAATTGCAAAA
CGAACTGGTGGAAGACCCGGAGCGCGGCGATCTCATCAAGGGTGGTGGCGGTATCCGCAAGCTGCGCTATGCCATGCAAG
GGCGCGGCAAGAGCGGCGGGGTTCGGTTGATTTACTACTGGGTCAAGGACAACCACCAGATTTACATGCTGGTAGTGTAT
CCGAAGTCAAAAAAGGACGATCTGACCGATCAGGAAACTGCCATCCTGCGCAACTATGTGAAGGAGCTATGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10682.35 Da        Isoelectric Point: 10.6827

>AT33504 WP_147073719.1 NZ_AP021884:411552-411842 [Sulfuriferula plumbiphila]
MEKTLFDDLVQSLKEADAITKGKTKASRRFDVTPPDVKAVREQIGLSQSEFARLMRVSIKTLQNWEQHRRNPTGPAAALL
KIVSTAPEVALKSLHA

Download         Length: 291 bp

>AT33504 NZ_AP021884:411552-411842 [Sulfuriferula plumbiphila]
ATGGAAAAAACACTGTTTGATGATCTGGTGCAAAGCCTGAAAGAAGCCGATGCCATCACCAAAGGCAAAACCAAAGCTTC
GCGCCGATTCGATGTCACGCCGCCCGATGTCAAGGCGGTGCGCGAGCAAATTGGGCTATCGCAAAGCGAGTTTGCCCGGC
TGATGCGGGTCAGCATCAAAACGCTACAGAATTGGGAGCAGCACCGCCGCAATCCGACCGGCCCCGCTGCCGCACTGCTC
AAGATCGTATCAACTGCCCCGGAAGTGGCGCTCAAGTCGTTACACGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References