Detailed information of TA system TA033503

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): prlF-yhaV (relBE)/YhaV-PrlF
• Location: 400992..401833
• Replicon: chromosome
• Accession: NZ_AP021884
• Organism: Sulfuriferula plumbiphila strain Gro7

Toxin (Protein)

• Gene name: yhaV
• Uniprot ID: -
• Locus tag: GZH91_RS02065
• Protein ID: WP_147073735.1
• Coordinates: 401318..401833 (+)
• Length: 172 a.a.

Antitoxin (Protein)

• Gene name: prlF
• Uniprot ID: -
• Locus tag: GZH91_RS02060
• Protein ID: WP_147073737.1
• Coordinates: 400992..401321 (+)
• Length: 110 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GZH91_RS02050	396156..397034	-	879	WP_198415364.1	hypothetical protein	-
GZH91_RS02055	397380..400526	+	3147	WP_198415365.1	hypothetical protein	-
GZH91_RS02060	400992..401321	+	330	WP_147073737.1	type II toxin-antitoxin system PrlF family antitoxin	Antitoxin
GZH91_RS02065	401318..401833	+	516	WP_147073735.1	type II toxin-antitoxin system YhaV family toxin	Toxin
GZH91_RS02070	402244..402459	-	216	WP_147073733.1	AlpA family phage regulatory protein	-
GZH91_RS02075	403012..403851	-	840	WP_147073731.1	DUF1845 family protein	-
GZH91_RS02080	404323..404901	+	579	WP_198415366.1	hypothetical protein	-
GZH91_RS02085	404950..405198	+	249	WP_147073729.1	hypothetical protein	-
GZH91_RS02090	405209..405520	+	312	WP_147073727.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin endonuclease, YhaV (16-152)

Antitoxin

• PrlF antitoxin (8-107)

Sequences

Toxin

Protein

• Length: 172 a.a.
• Molecular weight: 19759.59 Da
• Isoelectric Point: 10.0437

>T33503 WP_147073735.1 NZ_AP021884:401318-401833 [Sulfuriferula plumbiphila]
MSGSEPAPLVVNRWTIFAHPLFLAQLEVLTRQVEGLKQKDPAGFTKKNATKRLAAIAKLVFEVIPQDPSRAEYRQGSTLG
EDRKHWFRAKFFQQYRLFFRYHASSKVIVFAWMNDDDTKRAFESSDDAYRVFKKMLESGHPPDDWDHLLAEAQSATRRLK
TSVDLLKGMEP

Nucleotide

• Length: 516 bp

>T33503 NZ_AP021884:401318-401833 [Sulfuriferula plumbiphila]
ATGAGCGGGAGTGAGCCCGCGCCATTGGTGGTTAACAGATGGACGATCTTTGCCCACCCCCTGTTCCTCGCCCAACTTGA
AGTGCTTACCCGGCAGGTCGAAGGGCTCAAGCAAAAAGACCCGGCCGGATTCACCAAAAAGAACGCAACCAAGCGGCTGG
CAGCGATTGCCAAGCTGGTGTTCGAGGTGATTCCGCAAGATCCGTCGCGGGCTGAATATAGGCAGGGCAGCACGCTCGGC
GAAGATCGCAAGCACTGGTTCCGCGCCAAGTTCTTCCAGCAGTACCGGCTGTTCTTCCGCTACCATGCGTCGAGCAAAGT
GATTGTGTTTGCTTGGATGAACGATGACGATACGAAGCGCGCCTTTGAAAGTAGCGACGACGCCTACCGGGTTTTCAAAA
AAATGCTGGAAAGTGGTCATCCGCCCGATGACTGGGATCATCTGCTGGCAGAGGCTCAATCCGCCACAAGGCGCTTGAAA
ACGAGCGTCGACTTGCTCAAGGGAATGGAACCGTGA

Antitoxin

Protein

• Length: 110 a.a.
• Molecular weight: 11968.47 Da
• Isoelectric Point: 4.4829

>AT33503 WP_147073737.1 NZ_AP021884:400992-401321 [Sulfuriferula plumbiphila]
MAATLEVESTLTDRYQTTVPETVRRALKLGKRDKIHYTIRPGGEVVLTRVDASEEDDPVLGQFLGFLARDIASHPERLQA
VDASLVQRIHSLVGGIEVDLDAVLSADDE

Nucleotide

• Length: 330 bp

>AT33503 NZ_AP021884:400992-401321 [Sulfuriferula plumbiphila]
ATGGCTGCCACCCTCGAAGTCGAATCCACCCTGACAGACCGCTACCAGACCACGGTGCCGGAAACTGTTCGCCGCGCCCT
TAAACTGGGCAAGCGGGACAAAATTCACTACACGATCCGTCCCGGTGGTGAGGTCGTGCTCACCCGCGTTGATGCCTCCG
AGGAAGACGACCCGGTGCTCGGGCAGTTCTTGGGTTTCTTGGCTCGCGACATTGCCAGTCATCCGGAACGGCTCCAGGCC
GTCGACGCCAGCCTCGTGCAGCGCATCCATTCATTGGTCGGTGGCATTGAAGTCGATCTCGACGCTGTCCTGTCGGCAGA
CGATGAATGA