Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3126292..3126871 Replicon chromosome
Accession NZ_AP021881
Organism Sulfuriferula nivalis strain SGTM

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag SFSGTM_RS15415 Protein ID WP_162085931.1
Coordinates 3126292..3126570 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag SFSGTM_RS15420 Protein ID WP_162085932.1
Coordinates 3126581..3126871 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SFSGTM_RS15375 3121848..3122336 - 489 WP_162085923.1 DUF2867 domain-containing protein -
SFSGTM_RS15380 3122409..3123101 - 693 WP_162085924.1 aspartate/glutamate racemase family protein -
SFSGTM_RS15385 3123137..3123487 - 351 WP_162085925.1 hypothetical protein -
SFSGTM_RS15390 3123492..3123851 - 360 WP_162085926.1 hypothetical protein -
SFSGTM_RS15395 3123929..3124444 - 516 WP_162085927.1 hypothetical protein -
SFSGTM_RS15400 3124473..3124766 - 294 WP_162085928.1 DUF1330 domain-containing protein -
SFSGTM_RS15405 3124799..3124936 + 138 WP_162085929.1 hypothetical protein -
SFSGTM_RS15410 3125090..3125581 - 492 WP_162085930.1 thiol peroxidase -
SFSGTM_RS15415 3126292..3126570 + 279 WP_162085931.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SFSGTM_RS15420 3126581..3126871 + 291 WP_162085932.1 HigA family addiction module antidote protein Antitoxin
SFSGTM_RS15425 3126948..3127259 - 312 WP_162085933.1 hypothetical protein -
SFSGTM_RS15430 3127256..3127885 - 630 WP_162085934.1 ParA family protein -
SFSGTM_RS15435 3128108..3128533 - 426 WP_162085935.1 hypothetical protein -
SFSGTM_RS15440 3128869..3130146 + 1278 WP_162085936.1 carbohydrate porin -
SFSGTM_RS15445 3130169..3131356 + 1188 WP_198420574.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-90)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10688.12 Da        Isoelectric Point: 9.9518

>T33494 WP_162085931.1 NZ_AP021881:3126292-3126570 [Sulfuriferula nivalis]
MIKTFHHKGLEQFFRDGSKAGIQPHHANKLRIMLTMLDNAKKPTDMNAPGWRFHSLVGNLTGHYSVTINGNWRMTFRFDG
NDAELVNYQDYH

Download         Length: 279 bp

>T33494 NZ_AP021881:3126292-3126570 [Sulfuriferula nivalis]
ATGATTAAAACTTTTCATCACAAAGGACTTGAGCAATTCTTCCGAGATGGAAGCAAAGCTGGAATACAGCCACACCACGC
TAATAAGCTACGCATCATGCTAACCATGCTAGACAATGCGAAAAAACCAACGGATATGAATGCACCAGGATGGCGGTTTC
ACTCATTAGTTGGCAATCTTACAGGGCATTATTCCGTAACGATTAATGGTAATTGGCGAATGACATTCCGCTTCGATGGC
AATGATGCCGAGCTGGTGAATTATCAGGACTATCATTAG

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10623.35 Da        Isoelectric Point: 9.3476

>AT33494 WP_162085932.1 NZ_AP021881:3126581-3126871 [Sulfuriferula nivalis]
MSRMNNPAHPGEVLREWIPEGMTITNAAKALQVSRVTLSKVLNGNGGITAGMALRLASWLCTSPEVWLGMQTQWDLWQAE
QQPIPKIKPLDRTATL

Download         Length: 291 bp

>AT33494 NZ_AP021881:3126581-3126871 [Sulfuriferula nivalis]
ATGAGCAGAATGAACAATCCAGCACATCCTGGTGAAGTATTGCGTGAATGGATACCAGAAGGCATGACGATAACGAATGC
AGCAAAGGCATTACAAGTGTCCCGCGTCACGCTTTCCAAGGTGTTAAATGGTAATGGTGGCATAACAGCAGGCATGGCAT
TACGTCTTGCGTCATGGCTGTGCACATCTCCTGAAGTTTGGCTTGGGATGCAAACACAGTGGGATCTGTGGCAAGCCGAG
CAACAACCAATTCCAAAGATCAAACCGCTTGACCGAACAGCAACTCTTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References