Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 5880559..5881127 Replicon chromosome
Accession NZ_AP021879
Organism Desulfosarcina ovata subsp. ovata strain oXyS1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag GN112_RS25775 Protein ID WP_155312799.1
Coordinates 5880849..5881127 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag GN112_RS25770 Protein ID WP_155312798.1
Coordinates 5880559..5880849 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GN112_RS25750 5875733..5876851 + 1119 WP_155310575.1 IS110 family transposase -
GN112_RS34075 5877249..5877476 - 228 WP_197743401.1 NAD(P)H-dependent oxidoreductase -
GN112_RS25760 5878252..5879592 + 1341 WP_155308519.1 group II intron reverse transcriptase/maturase -
GN112_RS25765 5879666..5880400 - 735 WP_155312797.1 DUF2971 domain-containing protein -
GN112_RS25770 5880559..5880849 - 291 WP_155312798.1 HigA family addiction module antidote protein Antitoxin
GN112_RS25775 5880849..5881127 - 279 WP_155312799.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GN112_RS25780 5882139..5882585 - 447 WP_155312800.1 hypothetical protein -
GN112_RS25785 5882837..5884321 - 1485 WP_197743402.1 group II intron reverse transcriptase/maturase -
GN112_RS25790 5885568..5885873 - 306 WP_155312802.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(3-83)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10890.47 Da        Isoelectric Point: 9.5735

>T33458 WP_155312799.1 NZ_AP021879:c5881127-5880849 [Desulfosarcina ovata subsp. ovata]
MIKSFKHKGLRKFFETGNLAGIQPDHRQKLRIRLIALDTATCIEDMNTPGWRLHSLKGDRQGLWAIDVNRNWRIVFEFKD
GNAYIVDYEDYH

Download         Length: 279 bp

>T33458 NZ_AP021879:c5881127-5880849 [Desulfosarcina ovata subsp. ovata]
ATGATAAAATCATTTAAACATAAAGGGCTGCGTAAATTTTTTGAAACTGGTAATTTGGCTGGCATTCAACCGGACCACAG
GCAAAAACTTAGAATTCGACTAATTGCACTTGATACTGCAACATGCATCGAAGATATGAACACTCCAGGTTGGCGGCTCC
ACAGTTTAAAAGGTGATCGTCAGGGATTATGGGCGATTGATGTAAACCGAAATTGGCGTATCGTTTTTGAGTTTAAAGAT
GGTAATGCCTATATCGTAGACTATGAGGATTATCACTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10663.39 Da        Isoelectric Point: 8.9799

>AT33458 WP_155312798.1 NZ_AP021879:c5880849-5880559 [Desulfosarcina ovata subsp. ovata]
MAMYNPPHPGEFIKDVYLEPLGVSPRSVALRLKVSPSTFSRIIKAQSAISPGMALRLSKCLGRSPESWLHMQDSYDLWQA
KQNVDISNIEPLAIPA

Download         Length: 291 bp

>AT33458 NZ_AP021879:c5880849-5880559 [Desulfosarcina ovata subsp. ovata]
ATGGCTATGTATAACCCTCCCCATCCAGGGGAATTTATCAAGGATGTTTATCTGGAACCTCTGGGTGTATCACCCCGAAG
TGTTGCCTTACGGCTTAAAGTTTCTCCTTCAACCTTTTCAAGGATTATAAAAGCACAAAGTGCAATTAGTCCTGGAATGG
CTTTGCGTCTATCCAAATGTTTAGGCCGCAGCCCTGAGAGCTGGCTTCATATGCAGGATAGCTATGACCTTTGGCAAGCA
AAACAAAATGTTGATATTTCAAATATAGAGCCCTTGGCGATACCAGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References