Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 5859046..5859652 Replicon chromosome
Accession NZ_AP021879
Organism Desulfosarcina ovata subsp. ovata strain oXyS1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag GN112_RS25665 Protein ID WP_155312786.1
Coordinates 5859374..5859652 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag GN112_RS25660 Protein ID WP_174247676.1
Coordinates 5859046..5859360 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GN112_RS25635 5854543..5854809 - 267 WP_155312782.1 hypothetical protein -
GN112_RS25640 5854900..5855475 - 576 WP_155312783.1 hypothetical protein -
GN112_RS25645 5856280..5857623 + 1344 WP_174247675.1 group II intron reverse transcriptase/maturase -
GN112_RS25650 5857893..5858363 - 471 WP_155312784.1 hypothetical protein -
GN112_RS25655 5858435..5858902 - 468 WP_155312785.1 DUF5063 domain-containing protein -
GN112_RS25660 5859046..5859360 - 315 WP_174247676.1 HigA family addiction module antidote protein Antitoxin
GN112_RS25665 5859374..5859652 - 279 WP_155312786.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GN112_RS34070 5859809..5860375 - 567 Protein_5110 transposase -
GN112_RS25675 5861900..5862127 - 228 WP_155311985.1 hypothetical protein -
GN112_RS25680 5862124..5863314 - 1191 WP_155311984.1 transposase -
GN112_RS25685 5863311..5863523 - 213 WP_155311983.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(5-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10720.15 Da        Isoelectric Point: 9.2100

>T33457 WP_155312786.1 NZ_AP021879:c5859652-5859374 [Desulfosarcina ovata subsp. ovata]
MIKSFKHKGLEDFFYDGSKKGIRPEHADKIARILDRLNGANDIIDMNYPGSYLHKLTGNLKGQYSVRVSGNWRIFFKFID
GDAYVINYDDYH

Download         Length: 279 bp

>T33457 NZ_AP021879:c5859652-5859374 [Desulfosarcina ovata subsp. ovata]
ATGATTAAATCGTTCAAACATAAAGGACTCGAGGATTTCTTTTATGATGGTAGCAAAAAAGGAATCCGCCCTGAACATGC
TGATAAGATAGCAAGAATTTTAGATCGATTGAATGGCGCCAATGATATTATAGACATGAATTATCCTGGGTCATATTTAC
ATAAACTAACGGGAAACCTGAAAGGCCAATATTCGGTAAGAGTGTCTGGGAATTGGCGTATCTTTTTTAAATTCATTGAT
GGTGATGCATATGTCATTAATTACGACGATTATCACTAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12139.10 Da        Isoelectric Point: 10.6893

>AT33457 WP_174247676.1 NZ_AP021879:c5859360-5859046 [Desulfosarcina ovata subsp. ovata]
MRRMKRQPTHPGYILKLDYLEPLAISVTEMASNLNVSRKTLSKILNQKGAVTPDMALRLSRAFNTTPELWLNLQKQYDLW
QAEHSSNDWKRVRPLPDKLLHSNL

Download         Length: 315 bp

>AT33457 NZ_AP021879:c5859360-5859046 [Desulfosarcina ovata subsp. ovata]
ATGAGACGAATGAAACGACAACCAACACATCCTGGATACATCCTTAAATTAGACTATCTTGAGCCCTTGGCAATTTCCGT
AACAGAAATGGCTTCAAATTTAAATGTATCCAGAAAAACCTTATCAAAAATTTTAAACCAAAAGGGGGCTGTAACGCCTG
ATATGGCCTTACGGCTTTCAAGAGCTTTTAATACGACACCTGAATTGTGGCTGAATTTGCAAAAGCAGTATGATCTTTGG
CAAGCAGAACATTCCTCGAACGACTGGAAGCGTGTCCGTCCACTACCTGACAAACTGCTTCATTCTAACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References