33456

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 5562995..5564247 Replicon chromosome
Accession NZ_AP021879
Organism Desulfosarcina ovata subsp. ovata strain oXyS1

Toxin (Protein)


Gene name HipT Uniprot ID -
Locus tag GN112_RS24400 Protein ID WP_155312574.1
Coordinates 5563303..5564247 (+) Length 315 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID -
Locus tag GN112_RS24395 Protein ID WP_155312573.1
Coordinates 5562995..5563306 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GN112_RS24370 5559298..5560596 - 1299 WP_155312570.1 helix-turn-helix domain-containing protein -
GN112_RS24375 5560611..5561012 - 402 WP_155312571.1 DUF4234 domain-containing protein -
GN112_RS24380 5561172..5561411 - 240 WP_197743388.1 type II toxin-antitoxin system VapC family toxin -
GN112_RS24385 5561465..5562481 - 1017 WP_155312338.1 transposase -
GN112_RS24390 5562748..5563002 + 255 WP_155312572.1 helix-turn-helix transcriptional regulator -
GN112_RS24395 5562995..5563306 + 312 WP_155312573.1 HipA N-terminal domain-containing protein Antitoxin
GN112_RS24400 5563303..5564247 + 945 WP_155312574.1 HipA domain-containing protein Toxin
GN112_RS24405 5564736..5564837 + 102 WP_155312575.1 hypothetical protein -
GN112_RS24410 5565045..5566358 + 1314 WP_155312576.1 4Fe-4S binding protein -
GN112_RS24415 5566388..5568610 + 2223 WP_162459100.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(51-268)

Antitoxin

HipA, N-terminal subdomain 1

(4-99)


Sequences

Toxin        


Download         Length: 315 a.a.        Molecular weight: 35675.55 Da        Isoelectric Point: 10.0488

>T33456 WP_155312574.1 NZ_AP021879:5563303-5564247 [Desulfosarcina ovata subsp. ovata]
MNTCLITYATCEGRYSPQGLRKLSRSLKQLKDFPYTAADQIVEAAARAPKMSIQGVQPKLSAVLNARQNGFELVDTGGRY
ILKPQNPQYRHLPENEDLSMRLAEAAGIPVPLHGLIYSKDGSLTYFIKRFDREGKKKIAVEDFAQLMGLNRDTKYDASME
KVAQVIDRYCTFPAVEKIKLFRLTLVNFLVGNEDMHVKNFSLMTRQGKVELTPAYDILNTTIVLSKAKEEIALPIKGKKR
KLSADILVDYFGLTRLELNRKIVSSVLETFKNVSSIWNNLIAVSFLPNEVKTEYKRLVDERFERLLKGSFLLSK

Download         Length: 945 bp

>T33456 NZ_AP021879:5563303-5564247 [Desulfosarcina ovata subsp. ovata]
ATGAACACCTGCCTGATTACCTATGCGACGTGTGAGGGCAGGTACTCCCCCCAGGGACTGAGAAAACTGTCCAGAAGTCT
CAAGCAGCTTAAGGATTTTCCCTATACCGCTGCGGATCAGATTGTTGAAGCCGCCGCCCGTGCTCCAAAAATGTCAATCC
AGGGGGTTCAGCCCAAGCTCAGTGCCGTCCTGAATGCCCGCCAAAACGGATTCGAGCTTGTGGATACTGGAGGTCGCTAC
ATTCTAAAACCTCAAAATCCACAATACAGGCACCTGCCTGAGAATGAAGACCTGAGCATGCGCCTGGCGGAGGCAGCCGG
CATTCCGGTCCCGCTTCATGGACTGATTTACTCCAAAGACGGCTCCCTGACCTACTTCATCAAGCGGTTTGACCGGGAAG
GAAAAAAAAAGATTGCCGTTGAGGATTTCGCCCAACTCATGGGCCTGAACCGGGATACCAAATACGACGCCTCCATGGAA
AAAGTCGCGCAAGTCATTGACCGGTACTGCACCTTCCCGGCAGTCGAAAAAATAAAACTGTTCAGATTGACGCTGGTGAA
TTTCCTGGTCGGTAACGAAGATATGCACGTGAAAAACTTTTCGCTGATGACCCGGCAGGGCAAGGTGGAATTGACACCTG
CTTACGACATTCTGAACACCACCATTGTGCTATCAAAAGCGAAAGAGGAGATCGCGCTGCCGATCAAAGGGAAAAAGCGC
AAGCTAAGTGCCGACATTCTGGTCGATTATTTTGGCCTGACCAGGCTAGAACTGAACCGCAAAATCGTTTCCTCGGTGTT
AGAAACCTTTAAAAATGTTTCGTCAATATGGAATAATCTCATCGCGGTCAGCTTTCTGCCGAACGAAGTGAAAACGGAAT
ACAAACGTTTGGTTGATGAACGATTCGAAAGATTGCTGAAAGGATCGTTCCTCCTCAGCAAGTAA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11546.26 Da        Isoelectric Point: 4.4805

>AT33456 WP_155312573.1 NZ_AP021879:5562995-5563306 [Desulfosarcina ovata subsp. ovata]
MRKADVFMHDVRAGVLEELSPRTTFRFTYDPAYNGPPVSLTAAVRPEPYTYETFPPFLEGLLPEGYNLEALLRAMKIDRQ
DLLSQLLAVGGDMVGAVTVREIE

Download         Length: 312 bp

>AT33456 NZ_AP021879:5562995-5563306 [Desulfosarcina ovata subsp. ovata]
ATGCGTAAGGCGGATGTCTTCATGCATGATGTCCGTGCCGGCGTTCTGGAGGAGCTTTCACCGCGGACAACGTTTCGGTT
CACTTATGATCCGGCATACAACGGCCCTCCGGTTTCCCTGACAGCGGCTGTCCGACCTGAGCCGTACACGTATGAAACCT
TTCCTCCCTTTCTGGAGGGGTTGCTGCCCGAAGGATACAATCTGGAGGCTCTCCTTAGAGCTATGAAAATTGACCGGCAG
GATTTACTCAGTCAGCTTCTGGCGGTGGGAGGGGATATGGTTGGTGCGGTGACGGTGCGGGAGATTGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References