Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1031793..1032438 Replicon chromosome
Accession NZ_AP021879
Organism Desulfosarcina ovata subsp. ovata strain oXyS1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag GN112_RS04595 Protein ID WP_155314132.1
Coordinates 1032121..1032438 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag GN112_RS04590 Protein ID WP_155309149.1
Coordinates 1031793..1032107 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GN112_RS04570 1027765..1028706 + 942 WP_155309146.1 radical SAM protein -
GN112_RS04575 1028757..1029341 + 585 WP_155309147.1 peptidyl-prolyl cis-trans isomerase -
GN112_RS04580 1029759..1031039 - 1281 WP_155314131.1 DEAD/DEAH box helicase -
GN112_RS04585 1031201..1031383 - 183 WP_155309148.1 hypothetical protein -
GN112_RS04590 1031793..1032107 - 315 WP_155309149.1 HigA family addiction module antidote protein Antitoxin
GN112_RS04595 1032121..1032438 - 318 WP_155314132.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GN112_RS04600 1032453..1032671 - 219 WP_155309150.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
GN112_RS04605 1032941..1033393 + 453 WP_155309151.1 GNAT family N-acetyltransferase -
GN112_RS04610 1033520..1034488 - 969 WP_155309152.1 ABC transporter substrate-binding protein -
GN112_RS04615 1034524..1035909 - 1386 WP_155309153.1 sigma-54 dependent transcriptional regulator -
GN112_RS04620 1035948..1036634 - 687 WP_155309154.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(15-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(19-69)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12065.45 Da        Isoelectric Point: 6.9879

>T33448 WP_155314132.1 NZ_AP021879:c1032438-1032121 [Desulfosarcina ovata subsp. ovata]
MDGEDHAASEADVRFKSFKHKGIEDFFYDGSKKGIRPEHANKIARILDRLNGANDIIDMNYPGSYLHKLTGSLKGQYSVR
VSGNWRIFFKFIDGDAYVVNYDDYH

Download         Length: 318 bp

>T33448 NZ_AP021879:c1032438-1032121 [Desulfosarcina ovata subsp. ovata]
CTGGACGGCGAGGATCATGCCGCCAGTGAAGCAGACGTTCGCTTCAAATCGTTCAAACATAAAGGGATAGAGGATTTCTT
TTATGATGGTAGCAAAAAAGGAATCCGCCCTGAACATGCTAATAAAATAGCAAGAATATTAGATCGATTGAATGGCGCCA
ATGATATTATAGACATGAATTATCCTGGGTCATATTTACATAAACTAACTGGAAGCCTGAAAGGACAATATTCGGTGAGA
GTGTCTGGGAATTGGCGTATCTTTTTTAAATTCATAGATGGTGATGCATATGTCGTTAATTACGACGATTATCACTAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12113.02 Da        Isoelectric Point: 10.6893

>AT33448 WP_155309149.1 NZ_AP021879:c1032107-1031793 [Desulfosarcina ovata subsp. ovata]
MRRMKRQPTHPGYILKSDYLEPLAISVTEMASNLNVSRKTLSKILNQKGAVTPDMALRLSRAFNTTPELWLNLQKNYDLW
QAEHSSNDWKRVRPLPEKLLHSNL

Download         Length: 315 bp

>AT33448 NZ_AP021879:c1032107-1031793 [Desulfosarcina ovata subsp. ovata]
ATGAGACGAATGAAACGACAACCAACACATCCTGGATACATCCTTAAATCAGACTATCTTGAGCCCTTGGCGATTTCAGT
AACAGAAATGGCTTCAAATTTAAATGTATCCAGAAAAACCTTGTCAAAAATTTTAAACCAAAAGGGGGCTGTTACTCCTG
ATATGGCCTTGCGGCTTTCAAGAGCTTTTAATACGACTCCTGAATTGTGGCTGAATTTGCAAAAGAATTATGATCTGTGG
CAAGCAGAACATTCTTCTAACGACTGGAAGCGTGTCCGTCCACTACCCGAAAAACTGCTTCATTCTAACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References