Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3515713..3516320 Replicon chromosome
Accession NZ_AP021876
Organism Desulfosarcina ovata subsp. sediminis strain 28bB2T

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag GN113_RS15540 Protein ID WP_155322979.1
Coordinates 3516039..3516320 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag GN113_RS15535 Protein ID WP_155322978.1
Coordinates 3515713..3516027 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GN113_RS15520 3511086..3511325 + 240 WP_155322977.1 toxin-antitoxin system HicB family antitoxin -
GN113_RS15525 3511447..3512787 - 1341 WP_155321404.1 group II intron reverse transcriptase/maturase -
GN113_RS15530 3513526..3514866 - 1341 WP_155321404.1 group II intron reverse transcriptase/maturase -
GN113_RS15535 3515713..3516027 - 315 WP_155322978.1 HigA family addiction module antidote protein Antitoxin
GN113_RS15540 3516039..3516320 - 282 WP_155322979.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GN113_RS15545 3517024..3517611 - 588 WP_197910480.1 transposase -
GN113_RS15550 3517845..3518060 + 216 WP_197910481.1 hypothetical protein -
GN113_RS15555 3518210..3518986 - 777 WP_155322981.1 DUF169 domain-containing protein -
GN113_RS15560 3519040..3519453 - 414 WP_155322982.1 DMT family transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(10-101)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10998.67 Da        Isoelectric Point: 10.0085

>T33428 WP_155322979.1 NZ_AP021876:c3516320-3516039 [Desulfosarcina ovata subsp. sediminis]
MIKSFADKETQQLFIKGKSKRLPPDLIKRAIRRLEFINFAITLNDLKVPPSNRLHALEGNREGQHSISINKQWRICFRFI
ENDAYDVEITDYH

Download         Length: 282 bp

>T33428 NZ_AP021876:c3516320-3516039 [Desulfosarcina ovata subsp. sediminis]
ATGATAAAATCGTTTGCCGACAAAGAGACACAACAGCTTTTTATCAAAGGCAAATCAAAACGACTACCGCCTGATTTGAT
AAAAAGAGCCATAAGGCGCTTGGAATTCATCAATTTTGCGATAACGCTTAATGATCTCAAAGTGCCTCCAAGCAACCGGC
TACATGCATTAGAAGGTAACCGAGAGGGACAACATTCCATATCGATCAATAAACAATGGCGAATATGTTTTCGTTTTATC
GAAAATGATGCATATGATGTCGAAATAACCGATTACCATTGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11795.48 Da        Isoelectric Point: 8.9107

>AT33428 WP_155322978.1 NZ_AP021876:c3516027-3515713 [Desulfosarcina ovata subsp. sediminis]
MSIPNTGKRQISPTHPGEILKEDFMPDFGLNATSLASALGVSRQTINEILRERRAVTPSMALRLSRLFGNSPEFWLNIQH
AFDLWDSEQRFKKELAQIHPLHAA

Download         Length: 315 bp

>AT33428 NZ_AP021876:c3516027-3515713 [Desulfosarcina ovata subsp. sediminis]
ATGAGCATACCTAATACAGGAAAAAGACAGATTTCCCCGACACATCCCGGCGAAATTCTCAAAGAAGATTTCATGCCGGA
TTTTGGCCTGAACGCTACATCATTGGCATCGGCCTTAGGAGTGTCACGGCAAACCATCAATGAAATTTTAAGAGAACGAC
GGGCAGTAACACCCTCAATGGCATTGCGATTGTCACGTCTTTTTGGAAATTCGCCAGAATTTTGGCTGAACATCCAGCAT
GCATTTGATTTGTGGGACTCTGAACAACGCTTCAAAAAAGAACTTGCTCAAATTCATCCTCTGCATGCCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References