Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2765368..2765870 Replicon chromosome
Accession NZ_AP021875
Organism Desulfosarcina widdelii strain PP31

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag GN111_RS12990 Protein ID WP_155304158.1
Coordinates 2765616..2765870 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag GN111_RS12985 Protein ID WP_155304157.1
Coordinates 2765368..2765619 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GN111_RS12960 2761035..2761625 + 591 WP_155304152.1 TetR/AcrR family transcriptional regulator -
GN111_RS12965 2761643..2762002 + 360 WP_155304153.1 hypothetical protein -
GN111_RS12970 2762100..2762930 - 831 WP_155304154.1 GMP synthase -
GN111_RS12975 2762981..2764339 - 1359 WP_155304155.1 FAD-dependent oxidoreductase -
GN111_RS12980 2764696..2765274 - 579 WP_155304156.1 GNAT family N-acetyltransferase -
GN111_RS12985 2765368..2765619 + 252 WP_155304157.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
GN111_RS12990 2765616..2765870 + 255 WP_155304158.1 Txe/YoeB family addiction module toxin Toxin
GN111_RS12995 2765918..2766541 - 624 WP_155304159.1 TetR/AcrR family transcriptional regulator -
GN111_RS13000 2766744..2767964 + 1221 WP_155304160.1 alcohol dehydrogenase catalytic domain-containing protein -
GN111_RS13005 2767993..2768352 + 360 WP_155304161.1 hypothetical protein -
GN111_RS13010 2768370..2770037 + 1668 WP_155304162.1 thiamine pyrophosphate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2531955..2791032 259077


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10193.66 Da        Isoelectric Point: 10.0159

>T33416 WP_155304158.1 NZ_AP021875:2765616-2765870 [Desulfosarcina widdelii]
VKLIFSDHAWDDYIYWQKTDKKILRRINTLIKETKRNPFEGVGKPEPLKHALSGYWSRRISDEHRFVYKVSEDAINIAQL
RYHY

Download         Length: 255 bp

>T33416 NZ_AP021875:2765616-2765870 [Desulfosarcina widdelii]
GTGAAGCTCATCTTTTCAGACCATGCCTGGGACGATTATATATACTGGCAAAAAACTGACAAAAAAATCCTTCGCCGTAT
CAACACCCTCATAAAGGAGACAAAACGCAACCCTTTTGAGGGTGTCGGCAAACCTGAACCATTGAAACATGCACTTTCCG
GCTATTGGTCCAGACGAATAAGCGACGAGCACAGATTCGTTTACAAGGTTTCAGAAGATGCCATTAATATTGCTCAACTG
AGGTATCACTATTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9459.80 Da        Isoelectric Point: 5.1665

>AT33416 WP_155304157.1 NZ_AP021875:2765368-2765619 [Desulfosarcina widdelii]
MKAITYTTARQNLAKTMENVCRDHAPMIVTRKSSESVVIMSLEDYEALEETAYLLRSPKNTRRLIESIAQLEDGKGNEKE
LVE

Download         Length: 252 bp

>AT33416 NZ_AP021875:2765368-2765619 [Desulfosarcina widdelii]
ATGAAAGCCATAACCTATACCACTGCAAGGCAAAACCTTGCGAAAACAATGGAAAACGTTTGCAGAGACCACGCGCCGAT
GATTGTAACGCGGAAATCATCGGAATCTGTGGTGATCATGTCTCTTGAGGACTATGAAGCCCTTGAGGAGACAGCCTATC
TGTTGCGGTCACCAAAAAACACTAGACGGCTGATTGAATCTATCGCTCAACTCGAAGATGGCAAAGGAAACGAAAAGGAG
CTTGTAGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References