Detailed information of TA system TA033415

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-YefM
• Location: 570040..570542
• Replicon: chromosome
• Accession: NZ_AP021875
• Organism: Desulfosarcina widdelii strain PP31

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: GN111_RS02670
• Protein ID: WP_155302263.1
• Coordinates: 570279..570542 (+)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: GN111_RS02665
• Protein ID: WP_155302262.1
• Coordinates: 570040..570282 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GN111_RS02645	565979..567511	+	1533	WP_155302258.1	hypothetical protein	-
GN111_RS02650	568887..569072	-	186	WP_155302259.1	hypothetical protein	-
GN111_RS02655	569047..569301	-	255	WP_155302260.1	hypothetical protein	-
GN111_RS02660	569305..569502	-	198	WP_155302261.1	hypothetical protein	-
GN111_RS02665	570040..570282	+	243	WP_155302262.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
GN111_RS02670	570279..570542	+	264	WP_155302263.1	Txe/YoeB family addiction module toxin	Toxin
GN111_RS02675	570576..571517	-	942	WP_170302093.1	tyrosine-type recombinase/integrase	-
GN111_RS02680	572049..572264	+	216	WP_155302265.1	hypothetical protein	-
GN111_RS02685	572277..572486	+	210	WP_155302266.1	hypothetical protein	-
GN111_RS02690	572487..572768	+	282	WP_155302267.1	hypothetical protein	-
GN111_RS02695	572855..573187	-	333	WP_155302268.1	M50 family metallopeptidase	-
GN111_RS02700	573199..573441	-	243	WP_155302269.1	hypothetical protein	-
GN111_RS02705	573489..573737	-	249	WP_155302270.1	hypothetical protein	-
GN111_RS02710	573781..574116	-	336	WP_155302271.1	DUF86 domain-containing protein	-
GN111_RS02715	574106..574402	-	297	WP_155302272.1	nucleotidyltransferase family protein	-
GN111_RS02720	574601..574924	-	324	WP_155302273.1	type II toxin-antitoxin system RelE/ParE family toxin	-
GN111_RS02725	574924..575205	-	282	WP_155307893.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	515994..604555	88561

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (4-86)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-69)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10057.69 Da
• Isoelectric Point: 10.4087

>T33415 WP_155302263.1 NZ_AP021875:570279-570542 [Desulfosarcina widdelii]
VSWTVVFTKQARKDAKKISAAGLKSKAEAIIQILRENPYQAPPSYEKLIGDLAGAYSRRINIQHRIVYQILDNEKTVKVI
RMWTHYE

Nucleotide

• Length: 264 bp

>T33415 NZ_AP021875:570279-570542 [Desulfosarcina widdelii]
GTGAGTTGGACAGTTGTTTTTACTAAACAGGCCAGAAAAGATGCAAAGAAAATATCTGCTGCAGGGCTCAAATCAAAAGC
CGAGGCAATAATTCAGATCCTGCGTGAGAACCCATATCAAGCGCCCCCTTCTTACGAAAAGCTCATCGGAGATTTAGCAG
GCGCATATTCAAGACGAATAAATATTCAGCACAGGATTGTCTACCAAATTCTTGATAACGAAAAAACAGTTAAGGTTATT
CGTATGTGGACGCACTATGAATAG

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9058.31 Da
• Isoelectric Point: 4.4143

>AT33415 WP_155302262.1 NZ_AP021875:570040-570282 [Desulfosarcina widdelii]
MPTLSATEARTKLYRLIDQTSLSHEPIIITGKRGNAVLISEGDWRSIQETIYLLNIPGMRESIREGLATPIEDCTEELDW

Nucleotide

• Length: 243 bp

>AT33415 NZ_AP021875:570040-570282 [Desulfosarcina widdelii]
ATGCCGACATTATCAGCAACCGAAGCGAGAACCAAACTTTACCGCCTAATTGATCAAACATCGTTATCACATGAGCCTAT
TATTATTACTGGCAAAAGGGGTAATGCAGTTCTTATATCTGAGGGGGACTGGCGTTCAATTCAAGAAACCATCTACCTTT
TGAACATTCCAGGTATGCGTGAGTCCATCCGTGAGGGTTTGGCGACTCCCATAGAGGATTGTACAGAGGAACTTGACTGG
TGA