Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4481071..4481678 Replicon chromosome
Accession NZ_AP021874
Organism Desulfosarcina alkanivorans strain PL12

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag DSCA_RS19600 Protein ID WP_155320488.1
Coordinates 4481397..4481678 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag DSCA_RS19595 Protein ID WP_155318035.1
Coordinates 4481071..4481385 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DSCA_RS19570 4476540..4477757 - 1218 WP_155318030.1 XRE family transcriptional regulator -
DSCA_RS19575 4478564..4478857 + 294 WP_155318031.1 type II toxin-antitoxin system RelE/ParE family toxin -
DSCA_RS19580 4478823..4479185 + 363 WP_155318032.1 HigA family addiction module antidote protein -
DSCA_RS19585 4479873..4480289 - 417 WP_155318033.1 type II toxin-antitoxin system HicB family antitoxin -
DSCA_RS19590 4480299..4480496 - 198 WP_167528071.1 type II toxin-antitoxin system HicA family toxin -
DSCA_RS19595 4481071..4481385 - 315 WP_155318035.1 HigA family addiction module antidote protein Antitoxin
DSCA_RS19600 4481397..4481678 - 282 WP_155320488.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DSCA_RS19605 4482020..4482481 + 462 WP_155318036.1 L-2-amino-thiazoline-4-carboxylic acid hydrolase -
DSCA_RS19610 4482456..4482890 + 435 WP_155318037.1 DUF4405 domain-containing protein -
DSCA_RS19615 4483262..4484980 - 1719 WP_155318038.1 DEAD/DEAH box helicase -
DSCA_RS19620 4484973..4486061 - 1089 WP_155318039.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(12-89)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10958.55 Da        Isoelectric Point: 10.0970

>T33412 WP_155320488.1 NZ_AP021874:c4481678-4481397 [Desulfosarcina alkanivorans]
MIKSFANKETQRLFVSGKSKRMPSDLLRRAIRRLEFIHFANDINDLLVPPSNRLHALKGDRKGQHSISINDQWRICFRFI
EGDAYDVEITDYH

Download         Length: 282 bp

>T33412 NZ_AP021874:c4481678-4481397 [Desulfosarcina alkanivorans]
ATGATAAAATCATTTGCCAATAAGGAAACCCAACGGTTATTCGTTTCTGGCAAATCGAAACGCATGCCTTCCGATTTATT
ACGAAGGGCAATAAGACGTTTAGAATTTATCCATTTTGCAAATGACATAAATGACCTTTTGGTGCCACCCAGTAACAGGC
TTCATGCTTTAAAAGGCGACAGGAAAGGCCAACATTCAATATCGATAAATGACCAGTGGCGAATTTGTTTTCGTTTTATC
GAAGGCGATGCTTACGATGTTGAGATTACCGATTACCATTAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12141.86 Da        Isoelectric Point: 9.7739

>AT33412 WP_155318035.1 NZ_AP021874:c4481385-4481071 [Desulfosarcina alkanivorans]
MAIPNSSKREIRPTHPGEMLREDFMPDYELKTTSMAKALGVSRQTINEILRERRAVSPAMALRLSRLFGNSPEFWLNVQH
SWDLWDSEQRYRKELSQIQPLNAA

Download         Length: 315 bp

>AT33412 NZ_AP021874:c4481385-4481071 [Desulfosarcina alkanivorans]
ATGGCTATACCTAACTCATCAAAGCGAGAAATCAGGCCAACTCACCCCGGCGAAATGCTTAGAGAGGATTTCATGCCGGA
CTATGAACTCAAAACGACTTCCATGGCAAAAGCCTTAGGTGTATCTCGCCAGACGATAAATGAAATTTTAAGAGAACGAC
GTGCGGTAAGTCCTGCTATGGCGTTAAGATTGTCTCGTCTTTTCGGCAATTCGCCCGAATTCTGGTTGAATGTGCAGCAT
TCATGGGACCTTTGGGATTCGGAGCAACGCTACAGAAAAGAATTGTCTCAAATCCAACCGTTGAATGCCGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References