Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4595696..4596405 Replicon chromosome
Accession NZ_AP020326
Organism Mycobacterium avium subsp. hominissuis strain JP-H-1

Toxin (Protein)


Gene name HigB2 Uniprot ID X7V9P5
Locus tag JPH1_RS21520 Protein ID WP_003873387.1
Coordinates 4595696..4596100 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name HigA2 Uniprot ID X7V856
Locus tag JPH1_RS21525 Protein ID WP_019732445.1
Coordinates 4596097..4596405 (+) Length 103 a.a.

Genomic Context

JPH1_RS21500JPH1_RS21505JPH1_RS21520JPH1_RS21525JPH1_RS21490JPH1_RS21495JPH1_RS21515JPH1_RS21535JPH1_RS21540JPH1_RS21545
Location: 4592907..4593215 (309 bp)
Type: Others
Protein ID: WP_003874400.1
Location: 4593258..4594022 (765 bp)
Type: Others
Protein ID: WP_023900746.1
Location: 4595696..4596100 (405 bp)
Type: Toxin
Protein ID: WP_003873387.1
Location: 4596097..4596405 (309 bp)
Type: Antitoxin
Protein ID: WP_019732445.1
Location: 4591028..4591606 (579 bp)
Type: Others
Protein ID: WP_011726026.1
Location: 4591697..4592508 (812 bp)
Type: Others
Protein ID: Protein_4196
Location: 4594179..4595378 (1200 bp)
Type: Others
Protein ID: WP_075362332.1
Location: 4596892..4598418 (1527 bp)
Type: Others
Protein ID: WP_019732444.1
Location: 4598513..4600129 (1617 bp)
Type: Others
Protein ID: WP_003873390.1
Location: 4600218..4600520 (303 bp)
Type: Others
Protein ID: WP_019732443.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
JPH1_RS214904591028..4591606-579WP_011726026.1sigma-70 family RNA polymerase sigma factor-
JPH1_RS214954591697..4592508-812Protein_4196hypothetical protein-
JPH1_RS215004592907..4593215+309WP_003874400.1WhiB family transcriptional regulator-
JPH1_RS215054593258..4594022+765WP_023900746.1superoxide dismutase family protein-
JPH1_RS215154594179..4595378-1200WP_075362332.1FAD-dependent oxidoreductase-
JPH1_RS215204595696..4596100+405WP_003873387.1type II toxin-antitoxin system RelE/ParE family toxinToxin
JPH1_RS215254596097..4596405+309WP_019732445.1helix-turn-helix transcriptional regulatorAntitoxin
JPH1_RS215354596892..4598418-1527WP_019732444.1adenylate/guanylate cyclase domain-containing protein-
JPH1_RS215404598513..4600129-1617WP_003873390.1chaperonin GroEL-
JPH1_RS215454600218..4600520-303WP_019732443.1co-chaperone GroES-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-109)

Antitoxin

HigA2-like, helix-turn-helix domain

(32-91)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15503.82 Da        Isoelectric Point: 10.3815

>T33366 WP_003873387.1 NZ_AP020326:4595696-4596100 [Mycobacterium avium subsp. hominissuis]
VRKWEVDLTLIEAWMDALDDEEYDNLIAALEQLEEHGPITRRPFVDTLEGSRHPNMKELRPRPTKAGAHIRVLFAFDTRS
RAIMLIAGDKAGNWSKWYAKHIPIADELFDAHQKRLHKAAAKATNRKPRKGKKR

Download         Length: 405 bp

>T33366 NZ_AP020326:4595696-4596100 [Mycobacterium avium subsp. hominissuis]
GTGCGGAAATGGGAGGTTGACCTGACTCTCATCGAAGCCTGGATGGACGCCCTCGATGACGAGGAGTACGACAACTTGAT
AGCAGCGCTCGAGCAGTTGGAGGAACACGGTCCAATTACCCGGCGGCCGTTTGTGGACACCCTTGAAGGGTCACGGCACC
CGAACATGAAGGAGCTCCGTCCGCGCCCCACGAAAGCTGGAGCCCACATTCGCGTGCTATTCGCCTTCGATACCCGGTCG
CGGGCGATCATGTTGATCGCTGGAGACAAGGCGGGGAATTGGTCCAAGTGGTATGCCAAGCACATTCCCATTGCCGACGA
GCTCTTCGATGCTCACCAAAAGCGTTTGCACAAGGCAGCAGCCAAAGCCACAAATCGGAAACCAAGGAAGGGTAAGAAAC
GATGA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11454.95 Da        Isoelectric Point: 10.0802

>AT33366 WP_019732445.1 NZ_AP020326:4596097-4596405 [Mycobacterium avium subsp. hominissuis]
MTNLDDMRRRRPGNRTRIDAIKAEMDREVAHYRLRELREAAGYTQTTLAAAIGVGQNRVSQMEHGDLGTSRVDTLRKYVE
ATGGELEVSVKRPDGSRVLLSL

Download         Length: 309 bp

>AT33366 NZ_AP020326:4596097-4596405 [Mycobacterium avium subsp. hominissuis]
ATGACCAATCTTGATGACATGCGCCGTCGCCGTCCCGGCAACCGGACCCGTATCGACGCGATCAAGGCGGAGATGGACCG
CGAGGTTGCCCACTACCGTCTCCGTGAACTGCGCGAGGCTGCCGGCTACACGCAGACGACTCTCGCTGCGGCTATTGGCG
TCGGGCAGAACCGCGTCTCGCAGATGGAACATGGCGATCTCGGCACCAGCCGGGTCGACACTCTCCGCAAGTACGTGGAA
GCGACTGGGGGTGAGCTGGAAGTGTCCGTCAAGCGTCCGGACGGGTCACGGGTTCTCCTCAGTCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBX7V9P5

Antitoxin

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Source
ID
Structure
AlphaFold DBX7V856

References