Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2460945..2461129 Replicon chromosome
Accession NZ_AP020324
Organism Staphylococcus aureus strain KUN1163

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2U0ISP5
Locus tag KUH140013_RS12435 Protein ID WP_000482652.1
Coordinates 2460945..2461052 (+) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2461069..2461129 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KUH140013_RS12410 2456307..2456780 + 474 WP_000456486.1 GyrI-like domain-containing protein -
KUH140013_RS12415 2456903..2458114 - 1212 WP_001192073.1 multidrug effflux MFS transporter -
KUH140013_RS12420 2458296..2458955 - 660 WP_000831298.1 membrane protein -
KUH140013_RS12425 2459015..2460157 - 1143 WP_001176863.1 glycerate kinase -
KUH140013_RS12430 2460425..2460811 + 387 WP_000779360.1 flippase GtxA -
KUH140013_RS12435 2460945..2461052 + 108 WP_000482652.1 type I toxin-antitoxin system Fst family toxin Toxin
- 2461069..2461129 - 61 - - Antitoxin
KUH140013_RS12440 2461755..2463518 + 1764 WP_001064825.1 ABC transporter ATP-binding protein/permease -
KUH140013_RS12445 2463543..2465276 + 1734 WP_000486487.1 ABC transporter ATP-binding protein/permease -
KUH140013_RS12450 2465507..2465674 + 168 Protein_2363 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T33351 WP_000482652.1 NZ_AP020324:2460945-2461052 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T33351 NZ_AP020324:2460945-2461052 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT33351 NZ_AP020324:c2461129-2461069 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2U0ISP5

Antitoxin

Download structure file

References