Detailed information of TA system TA033339

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 20133..20471
• Replicon: chromosome
• Accession: NZ_AP020324
• Organism: Staphylococcus aureus strain KUN1163

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: KUH140013_RS00105
• Protein ID: WP_011447039.1
• Coordinates: 20133..20309 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	20297..20471 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KUH140013_RS00085	17821..17973	+	153	WP_001000058.1	hypothetical protein	-
KUH140013_RS00090	18019..18306	+	288	WP_001262621.1	hypothetical protein	-
KUH140013_RS00095	18362..18736	+	375	WP_000340977.1	hypothetical protein	-
KUH140013_RS00100	19157..19930	+	774	WP_025174055.1	staphylococcal enterotoxin type P	-
KUH140013_RS00105	20133..20309	+	177	WP_011447039.1	putative holin-like toxin	Toxin
-	20297..20471	-	175	-	-	Antitoxin
KUH140013_RS00115	20521..20775	+	255	WP_000611512.1	phage holin	-
KUH140013_RS00120	20787..21542	+	756	WP_000861038.1	CHAP domain-containing protein	-
KUH140013_RS00125	21733..22224	+	492	WP_000919350.1	staphylokinase	-
KUH140013_RS00135	22874..23209	+	336	Protein_25	SH3 domain-containing protein	-
KUH140013_RS00140	23304..23753	-	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
KUH140013_RS00145	24438..24788	+	351	WP_000702263.1	complement inhibitor SCIN-A	-
KUH140013_RS00150	24841..25101	-	261	WP_001791826.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	see / sak / chp / scn	1..24788	24787

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T33339 WP_011447039.1 NZ_AP020324:20133-20309 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T33339 NZ_AP020324:20133-20309 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 175 bp

>AT33339 NZ_AP020324:c20471-20297 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Toxin

• PDB: 7NS1

Antitoxin