Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2422498..2422682 Replicon chromosome
Accession NZ_AP020322
Organism Staphylococcus aureus strain KUH180129

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2U0ISP5
Locus tag F6Y14_RS12245 Protein ID WP_000482652.1
Coordinates 2422498..2422605 (+) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2422622..2422682 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F6Y14_RS12220 2417860..2418333 + 474 WP_000456486.1 GyrI-like domain-containing protein -
F6Y14_RS12225 2418456..2419667 - 1212 WP_001192075.1 multidrug effflux MFS transporter -
F6Y14_RS12230 2419849..2420508 - 660 WP_000831298.1 membrane protein -
F6Y14_RS12235 2420568..2421710 - 1143 WP_001176863.1 glycerate kinase -
F6Y14_RS12240 2421978..2422364 + 387 WP_000779360.1 flippase GtxA -
F6Y14_RS12245 2422498..2422605 + 108 WP_000482652.1 type I toxin-antitoxin system Fst family toxin Toxin
- 2422622..2422682 - 61 - - Antitoxin
F6Y14_RS12250 2423308..2425071 + 1764 WP_001064825.1 ABC transporter ATP-binding protein/permease -
F6Y14_RS12255 2425096..2426829 + 1734 WP_000486487.1 ABC transporter ATP-binding protein/permease -
F6Y14_RS12260 2427060..2427227 + 168 Protein_2319 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T33329 WP_000482652.1 NZ_AP020322:2422498-2422605 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T33329 NZ_AP020322:2422498-2422605 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT33329 NZ_AP020322:c2422682-2422622 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2U0ISP5

Antitoxin

Download structure file

References