Detailed information of TA system TA033324

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 513014..513593
• Replicon: chromosome
• Accession: NZ_AP020322
• Organism: Staphylococcus aureus strain KUH180129

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: F6Y14_RS02835
• Protein ID: WP_001025401.1
• Coordinates: 513014..513259 (+)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	513228..513593 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F6Y14_RS02790	509032..509646	+	615	WP_000191464.1	hypothetical protein	-
F6Y14_RS02795	509643..509789	-	147	WP_001795334.1	hypothetical protein	-
F6Y14_RS02800	510067..510603	-	537	WP_150073891.1	hypothetical protein	-
F6Y14_RS02805	510621..511082	-	462	WP_000525004.1	hypothetical protein	-
F6Y14_RS02810	511095..511409	-	315	WP_000333630.1	helix-turn-helix domain-containing protein	-
F6Y14_RS02815	511561..511797	+	237	WP_001121027.1	helix-turn-helix domain-containing protein	-
F6Y14_RS02820	511811..512587	+	777	WP_001148544.1	Rha family transcriptional regulator	-
F6Y14_RS02825	512616..512759	+	144	WP_000939498.1	hypothetical protein	-
F6Y14_RS02830	512749..512958	-	210	WP_000642492.1	hypothetical protein	-
F6Y14_RS02835	513014..513259	+	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
F6Y14_RS02840	513228..513593	-	366	WP_001128433.1	hypothetical protein	Antitoxin
F6Y14_RS02845	513648..513863	+	216	WP_001097552.1	hypothetical protein	-
F6Y14_RS02850	513888..514151	+	264	WP_001124198.1	helix-turn-helix domain-containing protein	-
F6Y14_RS02855	514163..514324	+	162	WP_001285948.1	DUF1270 domain-containing protein	-
F6Y14_RS02860	514402..514725	+	324	WP_000174998.1	hypothetical protein	-
F6Y14_RS02865	514740..515102	+	363	WP_000985977.1	hypothetical protein	-
F6Y14_RS02870	515099..516265	+	1167	WP_061740011.1	DUF2800 domain-containing protein	-
F6Y14_RS02875	516291..516848	+	558	WP_000645045.1	DUF2815 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	504712..554177	49465

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T33324 WP_001025401.1 NZ_AP020322:513014-513259 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T33324 NZ_AP020322:513014-513259 [Staphylococcus aureus]
ATGAACATTCAAGAAGCAACTAAGATAGCTACAAAAAATCTTGTCTCTATGACACGGAAAGATTGGAAGGAAAGTCATCG
AACTAAGATATTACCAACAAATGATAGTTTTTTACAATGCATCATTTCAAATAGCGATGGGACAAACCTTATCAGATATT
GGCAACCTTCAGCCGATGACCTCATGGCAAATGATTGGGAAGTTATAAACCCAACTAGAGACCAGGAATTATTGAAGCAA
TTTTAG

Antitoxin

Nucleotide

• Length: 366 bp

>AT33324 NZ_AP020322:c513593-513228 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin