Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 1996409..1996593 Replicon chromosome
Accession NZ_AP020320
Organism Staphylococcus aureus strain KUH180062

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2U0ISP5
Locus tag F6Y17_RS10400 Protein ID WP_000482652.1
Coordinates 1996486..1996593 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 1996409..1996469 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F6Y17_RS10385 1991864..1992031 - 168 Protein_1962 hypothetical protein -
F6Y17_RS10390 1992262..1993995 - 1734 WP_000486487.1 ABC transporter ATP-binding protein/permease -
F6Y17_RS10395 1994020..1995783 - 1764 WP_001064825.1 ABC transporter ATP-binding protein/permease -
- 1996409..1996469 + 61 - - Antitoxin
F6Y17_RS10400 1996486..1996593 - 108 WP_000482652.1 type I toxin-antitoxin system Fst family toxin Toxin
F6Y17_RS10405 1996727..1997113 - 387 WP_000779360.1 flippase GtxA -
F6Y17_RS10410 1997381..1998523 + 1143 WP_001176863.1 glycerate kinase -
F6Y17_RS10415 1998583..1999242 + 660 WP_000831298.1 membrane protein -
F6Y17_RS10420 1999424..2000635 + 1212 WP_001192073.1 multidrug effflux MFS transporter -
F6Y17_RS10425 2000758..2001231 - 474 WP_000456486.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T33313 WP_000482652.1 NZ_AP020320:c1996593-1996486 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T33313 NZ_AP020320:c1996593-1996486 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT33313 NZ_AP020320:1996409-1996469 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2U0ISP5

Antitoxin

Download structure file

References