Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 1970914..1971431 Replicon chromosome
Accession NZ_AP020320
Organism Staphylococcus aureus strain KUH180062

Toxin (Protein)


Gene name yoeB Uniprot ID A0A3A3ATA4
Locus tag F6Y17_RS10260 Protein ID WP_000113265.1
Coordinates 1970914..1971180 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag F6Y17_RS10265 Protein ID WP_000584499.1
Coordinates 1971180..1971431 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F6Y17_RS10230 1966342..1966878 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
F6Y17_RS10235 1967112..1967936 - 825 WP_000572038.1 formate/nitrite transporter family protein -
F6Y17_RS10240 1968153..1968335 - 183 WP_000230292.1 hypothetical protein -
F6Y17_RS10245 1968419..1968886 - 468 WP_000153347.1 SRPBCC domain-containing protein -
F6Y17_RS10250 1969072..1970619 - 1548 WP_000727772.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
F6Y17_RS10255 1970808..1970879 - 72 Protein_1937 hypothetical protein -
F6Y17_RS10260 1970914..1971180 - 267 WP_000113265.1 Txe/YoeB family addiction module toxin Toxin
F6Y17_RS10265 1971180..1971431 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
F6Y17_RS10270 1971596..1971697 - 102 Protein_1940 hypothetical protein -
F6Y17_RS10275 1971704..1972303 - 600 WP_000162810.1 DsbA family protein -
F6Y17_RS10280 1972322..1972684 - 363 WP_000819843.1 DUF4467 domain-containing protein -
F6Y17_RS10285 1972939..1974189 + 1251 WP_001012225.1 FemA/FemB family glycyltransferase FmhA -
F6Y17_RS10290 1974286..1975017 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
F6Y17_RS10295 1975014..1975733 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-81)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10436.96 Da        Isoelectric Point: 10.0573

>T33312 WP_000113265.1 NZ_AP020320:c1971180-1970914 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T33312 NZ_AP020320:c1971180-1970914 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACAATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT33312 WP_000584499.1 NZ_AP020320:c1971431-1971180 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT33312 NZ_AP020320:c1971431-1971180 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7BWF

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References