Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2376848..2377032 Replicon chromosome
Accession NZ_AP020318
Organism Staphylococcus aureus strain KUH180038

Toxin (Protein)


Gene name SprA2 Uniprot ID Q2FVI9
Locus tag F6Y16_RS11930 Protein ID WP_000482650.1
Coordinates 2376848..2376955 (+) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2376972..2377032 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F6Y16_RS11905 2372211..2372684 + 474 WP_000456489.1 GyrI-like domain-containing protein -
F6Y16_RS11910 2372807..2374018 - 1212 WP_001192075.1 multidrug effflux MFS transporter -
F6Y16_RS11915 2374200..2374859 - 660 WP_000831298.1 membrane protein -
F6Y16_RS11920 2374919..2376061 - 1143 WP_001176863.1 glycerate kinase -
F6Y16_RS11925 2376329..2376715 + 387 WP_000779358.1 flippase GtxA -
F6Y16_RS11930 2376848..2376955 + 108 WP_000482650.1 type I toxin-antitoxin system Fst family toxin Toxin
- 2376972..2377032 - 61 - - Antitoxin
F6Y16_RS11935 2377583..2379346 + 1764 WP_001064838.1 ABC transporter ATP-binding protein/permease -
F6Y16_RS11940 2379371..2381104 + 1734 WP_000486494.1 ABC transporter ATP-binding protein/permease -
F6Y16_RS11945 2381335..2381502 + 168 WP_001790576.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T33286 WP_000482650.1 NZ_AP020318:2376848-2376955 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T33286 NZ_AP020318:2376848-2376955 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTATAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT33286 NZ_AP020318:c2377032-2376972 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2C9TTS8

Antitoxin

Download structure file

References