Detailed information of TA system TA033277

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 20169..20507
• Replicon: chromosome
• Accession: NZ_AP020318
• Organism: Staphylococcus aureus strain KUH180038

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: F6Y16_RS00105
• Protein ID: WP_011447039.1
• Coordinates: 20169..20345 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	20333..20507 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F6Y16_RS00085	17856..18008	+	153	WP_000654329.1	hypothetical protein	-
F6Y16_RS00090	18055..18342	+	288	WP_001040255.1	hypothetical protein	-
F6Y16_RS00095	18398..18772	+	375	WP_000340977.1	hypothetical protein	-
F6Y16_RS00100	19193..19966	+	774	WP_025174055.1	staphylococcal enterotoxin type P	-
F6Y16_RS00105	20169..20345	+	177	WP_011447039.1	putative holin-like toxin	Toxin
-	20333..20507	-	175	-	-	Antitoxin
F6Y16_RS00115	20557..20811	+	255	WP_000611512.1	phage holin	-
F6Y16_RS00120	20823..21578	+	756	WP_000861038.1	CHAP domain-containing protein	-
F6Y16_RS00125	21769..22260	+	492	WP_000920038.1	staphylokinase	-
F6Y16_RS00145	22911..23246	+	336	Protein_25	SH3 domain-containing protein	-
F6Y16_RS00150	23757..24107	+	351	WP_000702263.1	complement inhibitor SCIN-A	-
F6Y16_RS00155	24160..24420	-	261	WP_001791826.1	hypothetical protein	-
F6Y16_RS00165	24731..24910	-	180	WP_000669791.1	hypothetical protein	-
F6Y16_RS00170	25232..25482	-	251	Protein_29	sphingomyelin phosphodiesterase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	blaZ	see / sak / scn / hlb / map	4159..79753	75594

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T33277 WP_011447039.1 NZ_AP020318:20169-20345 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T33277 NZ_AP020318:20169-20345 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 175 bp

>AT33277 NZ_AP020318:c20507-20333 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Toxin

• PDB: 7NS1

Antitoxin