Detailed information of TA system TA033276

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/-
• Location: 2747157..2747571
• Replicon: chromosome
• Accession: NZ_AP020316
• Organism: Staphylococcus aureus strain KUH140331

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: F6Y18_RS13850
• Protein ID: WP_001065074.1
• Coordinates: 2747157..2747408 (+)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: F6Y18_RS13955
• Protein ID: WP_000028424.1
• Coordinates: 2747398..2747571 (+)
• Length: 58 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F6Y18_RS13790	2742803..2743462	-	660	WP_016028252.1	hypothetical protein	-
F6Y18_RS13795	2743508..2744278	+	771	WP_000190226.1	conserved phage C-terminal domain-containing protein	-
F6Y18_RS13800	2744288..2745061	+	774	WP_117216985.1	ATP-binding protein	-
F6Y18_RS13805	2745055..2745213	+	159	WP_015997089.1	hypothetical protein	-
F6Y18_RS13810	2745226..2745449	+	224	Protein_2617	DUF3269 family protein	-
F6Y18_RS13820	2745460..2745864	+	405	WP_000049784.1	DUF1064 domain-containing protein	-
F6Y18_RS13825	2745869..2746054	+	186	WP_001187242.1	DUF3113 family protein	-
F6Y18_RS13830	2746055..2746426	+	372	WP_115282698.1	hypothetical protein	-
F6Y18_RS13835	2746426..2746683	+	258	WP_000022720.1	DUF3310 domain-containing protein	-
F6Y18_RS13840	2746686..2746886	+	201	WP_000235326.1	hypothetical protein	-
F6Y18_RS13845	2746895..2747143	+	249	WP_117216382.1	hypothetical protein	-
F6Y18_RS13850	2747157..2747408	+	252	WP_001065074.1	DUF1024 family protein	Toxin
F6Y18_RS13955	2747398..2747571	+	174	WP_000028424.1	hypothetical protein	Antitoxin
F6Y18_RS13855	2747572..2747853	+	282	WP_000454994.1	hypothetical protein	-
F6Y18_RS13960	2747854..2748015	+	162	WP_172571785.1	hypothetical protein	-
F6Y18_RS13860	2748030..2748557	+	528	WP_117216380.1	dUTPase	-
F6Y18_RS13865	2748594..2748800	+	207	WP_000195810.1	DUF1381 domain-containing protein	-
F6Y18_RS13870	2748797..2748946	+	150	WP_000595265.1	transcriptional activator RinB	-
F6Y18_RS13875	2749105..2749755	+	651	WP_001005262.1	hypothetical protein	-
F6Y18_RS13880	2749755..2749955	+	201	WP_001794311.1	DUF1514 family protein	-
F6Y18_RS13885	2749983..2750399	+	417	WP_000590122.1	hypothetical protein	-
F6Y18_RS13890	2750631..2750930	+	300	WP_000988336.1	HNH endonuclease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	hlb	2726092..2750930	24838

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1024 (1-82)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9513.41 Da
• Isoelectric Point: 3.7128

>T33276 WP_001065074.1 NZ_AP020316:2747157-2747408 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILEGLPNAMQDALKEDIYLDEAVGIMTSQVVYKYEEEQE
NEY

Nucleotide

• Length: 252 bp

>T33276 NZ_AP020316:2747157-2747408 [Staphylococcus aureus]
ATGAATAATCGTGAACAAATTGAACAATCCGTTATAAGTGCTAGTGCGTATAACGGCAATGACACAGAGGGATTACTAAA
AGAGATTGAAGACGTGTATAAGAAAGCGCAAGCGTTTGATGAAATACTTGAGGGTTTACCTAATGCTATGCAAGATGCAC
TCAAAGAAGATATTTATCTTGATGAAGCAGTAGGGATTATGACGAGTCAAGTTGTCTATAAATATGAGGAGGAGCAGGAA
AATGAGTATTAG

Antitoxin

Protein

• Length: 58 a.a.
• Molecular weight: 6468.29 Da
• Isoelectric Point: 4.2484

>AT33276 WP_000028424.1 NZ_AP020316:2747398-2747571 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE

Nucleotide

• Length: 174 bp

>AT33276 NZ_AP020316:2747398-2747571 [Staphylococcus aureus]
ATGAGTATTAGTGTAGGAGATAAAGTATATAACCATGAAACAAACGAAAGTCTAGAGATTGTGCAATTGGTCGGAGATAT
TAGAGATACACATTATAAACTGTCTGATGATTCAGTTATTAGCATTATAGATTTTATTACTAAACCAATTTATCTAATTA
AGGGGGACGAGTGA