33271

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprG-sprF/-
Location 2597124..2597402 Replicon chromosome
Accession NZ_AP020316
Organism Staphylococcus aureus strain KUH140331

Toxin (Protein)


Gene name SprG3 Uniprot ID Q2FWA7
Locus tag F6Y18_RS12995 Protein ID WP_001802298.1
Coordinates 2597124..2597228 (+) Length 35 a.a.

Antitoxin (RNA)


Gene name SprF3
Locus tag -
Coordinates 2597224..2597402 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F6Y18_RS12970 2593921..2594703 + 783 WP_000908189.1 ABC transporter ATP-binding protein -
F6Y18_RS12975 2594771..2595628 + 858 WP_000370928.1 Cof-type HAD-IIB family hydrolase -
F6Y18_RS12985 2596286..2596444 - 159 WP_001792784.1 hypothetical protein -
F6Y18_RS12995 2597124..2597228 + 105 WP_001802298.1 hypothetical protein Toxin
- 2597224..2597402 - 179 - - Antitoxin
F6Y18_RS13000 2597670..2598761 - 1092 WP_000495681.1 hypothetical protein -
F6Y18_RS13005 2599027..2600007 - 981 WP_000019743.1 CDF family zinc efflux transporter CzrB -
F6Y18_RS13010 2600009..2600329 - 321 WP_000003755.1 Zn(II)-responsive metalloregulatory transcriptional repressor CzrA -
F6Y18_RS13015 2600481..2601146 + 666 WP_001024095.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)


Sequences

Toxin        


Download         Length: 35 a.a.        Molecular weight: 3906.77 Da        Isoelectric Point: 5.5724

>T33271 WP_001802298.1 NZ_AP020316:2597124-2597228 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Download         Length: 105 bp

>T33271 NZ_AP020316:2597124-2597228 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTGATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 179 bp

>AT33271 NZ_AP020316:c2597402-2597224 [Staphylococcus aureus]
GTGTTAAAATATATTTGTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGG
AAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAATGCCGGTCA
AAGCGAATAGAAGGTTATT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y9L9

Antitoxin

Download structure file

References