33269

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2343959..2344476 Replicon chromosome
Accession NZ_AP020316
Organism Staphylococcus aureus strain KUH140331

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag F6Y18_RS11655 Protein ID WP_000113262.1
Coordinates 2344210..2344476 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag F6Y18_RS11650 Protein ID WP_000584499.1
Coordinates 2343959..2344210 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F6Y18_RS11620 2339657..2340376 + 720 WP_000479576.1 amino acid ABC transporter permease -
F6Y18_RS11625 2340373..2341104 + 732 WP_000615470.1 amino acid ABC transporter ATP-binding protein -
F6Y18_RS11630 2341201..2342451 - 1251 WP_001012222.1 FemA/FemB family glycyltransferase FmhA -
F6Y18_RS11635 2342706..2343068 + 363 WP_000819843.1 DUF4467 domain-containing protein -
F6Y18_RS11640 2343087..2343686 + 600 WP_000162813.1 DsbA family protein -
F6Y18_RS11645 2343693..2343794 + 102 WP_001791744.1 hypothetical protein -
F6Y18_RS11650 2343959..2344210 + 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
F6Y18_RS11655 2344210..2344476 + 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
F6Y18_RS11660 2344511..2344582 + 72 Protein_2210 hypothetical protein -
F6Y18_RS11665 2344771..2346321 + 1551 WP_000727763.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
F6Y18_RS11670 2346507..2346974 + 468 WP_000153344.1 SRPBCC domain-containing protein -
F6Y18_RS11675 2347058..2347240 + 183 WP_000230294.1 hypothetical protein -
F6Y18_RS11680 2347457..2348281 + 825 WP_000572040.1 formate/nitrite transporter family protein -
F6Y18_RS11685 2348514..2349050 + 537 WP_000169317.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T33269 WP_000113262.1 NZ_AP020316:2344210-2344476 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T33269 NZ_AP020316:2344210-2344476 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT33269 WP_000584499.1 NZ_AP020316:2343959-2344210 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT33269 NZ_AP020316:2343959-2344210 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
AlphaFold DB T1YB60

References