Detailed information of TA system TA033259

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 18899..19237
• Replicon: chromosome
• Accession: NZ_AP020316
• Organism: Staphylococcus aureus strain KUH140331

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: F6Y18_RS00100
• Protein ID: WP_072353918.1
• Coordinates: 18899..19075 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	19063..19237 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F6Y18_RS00080	14066..17848	+	3783	WP_117216374.1	hypothetical protein	-
F6Y18_RS00085	17841..17993	+	153	WP_001000058.1	hypothetical protein	-
F6Y18_RS00090	18039..18326	+	288	WP_001262620.1	hypothetical protein	-
F6Y18_RS00095	18382..18756	+	375	WP_000340977.1	hypothetical protein	-
F6Y18_RS00100	18899..19075	+	177	WP_072353918.1	putative holin-like toxin	Toxin
-	19063..19237	-	175	-	-	Antitoxin
F6Y18_RS00110	19287..19541	+	255	WP_000611512.1	phage holin	-
F6Y18_RS00115	19553..20308	+	756	WP_000861038.1	CHAP domain-containing protein	-
F6Y18_RS00120	20499..20990	+	492	WP_000920041.1	staphylokinase	-
F6Y18_RS00135	21642..21977	+	336	Protein_24	SH3 domain-containing protein	-
F6Y18_RS00140	22488..22838	+	351	WP_000702262.1	complement inhibitor SCIN-A	-
F6Y18_RS00145	22891..23151	-	261	WP_001791826.1	hypothetical protein	-
F6Y18_RS00155	23462..23641	-	180	WP_000669789.1	hypothetical protein	-
F6Y18_RS00160	23963..24213	-	251	Protein_28	sphingomyelin phosphodiesterase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	sak / scn	1..22838	22837

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6810.43 Da
• Isoelectric Point: 9.9479

>T33259 WP_072353918.1 NZ_AP020316:18899-19075 [Staphylococcus aureus]
MDRWWLSEYKEVVPMLALLKSLERRCLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T33259 NZ_AP020316:18899-19075 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGTTGGCATTACTGAAATCTTTAGAAAGGAGATGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 175 bp

>AT33259 NZ_AP020316:c19237-19063 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Antitoxin