Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2379609..2379793 Replicon chromosome
Accession NZ_AP020313
Organism Staphylococcus aureus strain KUH140046

Toxin (Protein)


Gene name SprA2 Uniprot ID Q2FVI9
Locus tag F6Y15_RS11955 Protein ID WP_000482650.1
Coordinates 2379609..2379716 (+) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2379733..2379793 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F6Y15_RS11930 2374972..2375445 + 474 WP_000456489.1 GyrI-like domain-containing protein -
F6Y15_RS11935 2375568..2376779 - 1212 WP_001192075.1 multidrug effflux MFS transporter -
F6Y15_RS11940 2376961..2377620 - 660 WP_000831298.1 membrane protein -
F6Y15_RS11945 2377680..2378822 - 1143 WP_001176863.1 glycerate kinase -
F6Y15_RS11950 2379090..2379476 + 387 WP_000779358.1 flippase GtxA -
F6Y15_RS11955 2379609..2379716 + 108 WP_000482650.1 type I toxin-antitoxin system Fst family toxin Toxin
- 2379733..2379793 - 61 - - Antitoxin
F6Y15_RS11960 2380344..2382107 + 1764 WP_001064838.1 ABC transporter ATP-binding protein/permease -
F6Y15_RS11965 2382132..2383865 + 1734 WP_000486494.1 ABC transporter ATP-binding protein/permease -
F6Y15_RS11970 2384096..2384263 + 168 WP_001790576.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T33250 WP_000482650.1 NZ_AP020313:2379609-2379716 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T33250 NZ_AP020313:2379609-2379716 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTATAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT33250 NZ_AP020313:c2379793-2379733 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2C9TTS8

Antitoxin

Download structure file

References