Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2384340..2384857 Replicon chromosome
Accession NZ_AP020311
Organism Staphylococcus aureus strain KUH140013

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag F6Y13_RS11985 Protein ID WP_000113262.1
Coordinates 2384591..2384857 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag F6Y13_RS11980 Protein ID WP_000584499.1
Coordinates 2384340..2384591 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F6Y13_RS11950 2380037..2380756 + 720 WP_000479576.1 amino acid ABC transporter permease -
F6Y13_RS11955 2380753..2381484 + 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
F6Y13_RS11960 2381581..2382831 - 1251 WP_001012226.1 FemA/FemB family glycyltransferase FmhA -
F6Y13_RS11965 2383087..2383449 + 363 WP_000819843.1 DUF4467 domain-containing protein -
F6Y13_RS11970 2383468..2384067 + 600 WP_000162813.1 DsbA family protein -
F6Y13_RS11975 2384074..2384175 + 102 WP_001791744.1 hypothetical protein -
F6Y13_RS11980 2384340..2384591 + 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
F6Y13_RS11985 2384591..2384857 + 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
F6Y13_RS11990 2384892..2384963 + 72 Protein_2265 hypothetical protein -
F6Y13_RS11995 2385152..2386702 + 1551 WP_000727762.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
F6Y13_RS12000 2386888..2387355 + 468 WP_000153344.1 SRPBCC domain-containing protein -
F6Y13_RS12005 2387439..2387621 + 183 WP_000230294.1 hypothetical protein -
F6Y13_RS12010 2387838..2388662 + 825 WP_000572040.1 formate/nitrite transporter family protein -
F6Y13_RS12015 2388895..2389431 + 537 WP_000169317.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T33234 WP_000113262.1 NZ_AP020311:2384591-2384857 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T33234 NZ_AP020311:2384591-2384857 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT33234 WP_000584499.1 NZ_AP020311:2384340-2384591 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT33234 NZ_AP020311:2384340-2384591 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References